Publications by authors named "Husbands D"

High-throughput combinatorial metal complex synthesis has emerged as a powerful tool for rapidly generating and screening diverse libraries of metal complexes, enabling accelerated discovery in fields such as catalysis, medicinal chemistry, and materials science. By systematically combining building blocks under mild and efficient conditions, researchers can explore broad chemical spaces, increasing the likelihood of identifying complexes with desired properties. This method streamlines hit identification and optimisation, especially when integrated with high-throughput screening and data-driven approaches like machine learning.

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Article Synopsis
  • Fungi represent the most diverse kingdom of eukaryotic organisms, yet our understanding is hindered by a bias in data collection primarily from non-tropical regions.
  • Long-term studies (LTS) are critical for fully understanding fungal diversity, especially in tropical areas where such research is scarce.
  • This paper highlights the impact of tropical LTS, using ongoing research in the Pakaraima Mountains of Guyana, and discusses the lack of information on tropical fungi in public databases compared to other organisms.
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The Herrmann-Beller catalyst, Pd[(C^P)(μ-OAc)], is readily formed by reaction of the cyclic trimer of 'Pd(OAc)' with P(-tol). In the presence of hydroxide, Pd(C^P)(μ-OAc)] converts to [Pd(C^P)(μ -OH)]. Here, we report how this activated Pd precatalyst species, and related species, serve as a conduit for formation of higher order Pd clusters containing multiple cyclopalladated P(-tol) ligands.

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The ligand, P(-tolyl), is ubiquitous in applied synthetic chemistry and catalysis, particularly in Pd-catalyzed processes, which typically include Pd(OAc) (most commonly used as Pd(OAc)) as a precatalyst. The Herrmann-Beller palladacycle [Pd(C^P)(μ-OAc)] (where C^P = monocyclopalladated P(-tolyl)) is easily formed from reaction of Pd(OAc) with P(-tolyl). The mechanisms by which this precatalyst system operates are inherently complex, with studies previously implicating Pd nanoparticles (PdNPs) as reservoirs for active Pd species in arylative cross-coupling reactions.

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Following Ni-catalysed Suzuki-Miyaura cross coupling reactions, Ni is electrochemically removed on to the cathode, offering potential for recovery and reuse. The electrochemical recovery method, in combination with an analytical method developed for accurate quantification by HPLC, is expected to be broadly applicable to metal recovery following catalysis.

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Article Synopsis
  • * A total of 548 participants (average age 30, 54% women, 66% black) were involved, and results showed that CASA significantly increased participants' motivation to screen for STIs.
  • * While CASA was well-received and improved attitudes towards STI screening, the study notes a need for further research to see if these increased intentions translate into actual screening behavior.
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False political information-misinformation or disinformation-is widely spread on social media. Individual social media users play a large part in this. However, only a minority actively share false material.

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Background: The rapid evolution of conversational and generative artificial intelligence (AI) has led to the increased deployment of AI tools in healthcare settings. While these conversational AI tools promise efficiency and expanded access to healthcare services, there are growing concerns ethically, practically and in terms of inclusivity. This study aimed to identify activities which reduce bias in conversational AI and make their designs and implementation more equitable.

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The recent description of the putative fungal pathogen of greenheart trees, (Xylariaceae, Ascomycota), prompted a study of its secondary metabolism to access its ability to produce cytochalasans in culture. Solid-state fermentation of the ex-type strain on rice medium resulted in the isolation of a series of 19,20-epoxidated cytochalasins by means of preparative high-performance liquid chromatography (HPLC). Nine out of 10 compounds could be assigned to previously described structures, with one compound being new to science after structural assignment via nuclear magnetic resonance (NMR) assisted by high-resolution mass spectrometry (HRMS).

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[Pd (μ-PPh)(μ-OAc)(PPh)] is the reduction product of Pd(OAc)(PPh), generated by reaction of 'Pd(OAc)' with two equivalents of PPh. Here, we report that the reaction of [Pd (μ-PPh)(μ-OAc)(PPh)] with PPh results in a nuanced disproportionation reaction, forming [Pd(PPh)] and a phosphinito-bridged Pd-dinuclear complex, namely [Pd (μ-PPh){κ-P,O-μ-P(O)Ph}(κ-PPh)]. The latter complex is proposed to form by abstraction of an oxygen atom from an acetate ligand at Pd.

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In 2010-2011, a Xylaria sp. was documented growing from seeds of both Chlorocardium rodiei and Chlorocardium venenosum, a commercially valuable timber in Guyana. We conducted extensive surveys in 2015-2016, where this Xylaria sp.

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Xerocomus cyaneibrunnescens, Xerocomus potaroensis, and Xerocomus parvogracilis (Boletales, Basidiomycota) are described as new species from the Pakaraima Mountains of Guyana, in the central Guiana Shield region. These boletes occur in neotropical forests dominated by ectomycorrhizal (ECM) trees in the genus Dicymbe (Fabaceae subfam. Caesalpinioideae).

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This article outlines the process used by a multi-site acute academic health science centre to revise and manage its nursing policies and procedures. It describes how the organization progressed from a paper-based opinion-driven environment to an electronic evidence-based practice. The process was initiated on "Policy Day," a one-day collaborative workshop attended by the stakeholders.

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Experiments were conducted to examine a possible mechanism of activation of rat liver microsomal glycerol-3-phosphate acyltransferase (GPAT) by insulin. Fractions of Mr 1100 were prepared from hind-limb muscles of rats, which had been given intravenous injections of insulin or saline, by a procedure which involved acidification (pH 3.8) and heating (100 degrees C), followed by chromatography on Sephadex G-25 in 50 mM formic acid.

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Previous studies on the lipopigment from the livers of sheep affected with ceroid lipofuscinosis showed that the disease does not involve a defect in lipid metabolism or abnormal lipid peroxidation and that most of the lipopigment was proteinaceous. In this study, lipopigment was isolated from liver, kidney, pancreas, and brain of affected sheep without the use of proteolytic enzymes. Lipopigment from all tissues was two-thirds protein.

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The ceroid lipofuscinoses are inherited lysosomal diseases of children characterized by a fluorescent lipopigment stored in a variety of tissues. Defects in lipid metabolism or the control of lipid peroxidation have been postulated to explain their pathogenesis. In the present study, lipopigment was isolated from the liver of sheep affected with ceroid lipofuscinosis.

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The ceroid-lipofuscinoses are a group of inherited diseases of humans and animals characterised by brain atrophy and the storage of a fluorescent lipopigment. Brain grey matter phospholipid fatty acids of diseased sheep are compared with those of normal sheep. Phosphatidylethanolamine of diseased sheep contains more 18:1(n-9) and less 22:6(n-3) than normal and their phosphatidylcholine less 16:0.

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Mitochondria isolated from the livers of sheep and rats were shown to oxidize palmitate, oleate and linoleate in a tightly coupled manner, by monitoring the oxygen consumption associated with the degradation of these acids in the presence of 2mM-L-malate. Rat liver mitochondria oxidized linoleate and oleate at a rate 1.2-1.

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The mechanism by which the metabolic effects of insulin are transmitted is yet to be resolved. Second messengers mediating the action of insulin have been proposed and recently an insulin-dependent, peptide-like, heat- and acid-stable substance (Mr approx. 1000-3000) released from plasma membranes has been described which regulates the activity of key enzymes such as pyruvate dehydrogenase by altering its state of phosphorylation.

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Rabbits were fed diets containing 200 g.kg-1 coconut oil, palm oil, or safflower oil. Some of the diets also contained 200 g.

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Low-density lipoproteins floating between densities 1-006 and 1-063 g cm-3 were isolated by centrifugation of blood serum obtained from 24-h fasted pigs (Sus domesticus). This lipoprotein fraction contained two components with Sf 1-063 values of 3-4 and 2-3 at 20 degrees C when examined by analytical ultracentrifugation. Delipidation of the lipoprotein yielded 15% recovery of soluble protein.

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