Publications by authors named "Husam R Shadid"
Background: Statins are lipid-lowering agents with anti-inflammatory effects. Data surrounding the benefits of statins in patients with coronavirus disease 2019 (COVID-19) are conflicting. We sought to better understand the impact of statins in the context of COVID-19-related inflammation.
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- A study was conducted on adult COVID-19 patients hospitalized from February 2020 to October 2022 to identify effective inflammatory biomarkers for assessing patient risk during hospitalization.
- The biomarkers analyzed included suPAR, C-reactive protein (CRP), interleukin-6, procalcitonin, ferritin, and D-dimer; suPAR emerged as the strongest predictor of severe outcomes, such as death or the need for mechanical ventilation.
- A suPAR cutoff of 4.0 ng/mL was found to indicate low risk with high sensitivity and negative predictive value, suggesting it could be a valuable tool for triaging low-risk COVID-19 patients.
Background Use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARB) is thought to affect COVID-19 through modulating levels of angiotensin-converting enzyme 2, the cell entry receptor for SARS-CoV2. We sought to assess the association between ACEi/ARB, biomarkers of inflammation, and outcomes in patients hospitalized for COVID-19. Methods and Results We leveraged the ISIC (International Study of Inflammation in COVID-19), identified patients admitted for symptomatic COVID-19 between February 1, 2020 and June 1, 2021 for COVID-19, and examined the association between in-hospital ACEi/ARB use and all-cause death, need for ventilation, and need for dialysis.
View Article and Find Full Text PDFPurpose: Racial disparities in coronavirus disease 2019 (COVID-19) outcomes have been described. We sought to determine whether differences in inflammatory markers, use of COVID-19 therapies, enrollment in clinical trials, and in-hospital outcomes contribute to racial disparities between Black and non-Black patients hospitalized for COVID-19.
Methods: We leveraged a prospective cohort study that enrolled 1325 consecutive patients hospitalized for COVID-19, of whom 341 (25.
Objectives: To estimate the incidence, risk factors, and outcomes associated with in-hospital cardiac arrest and cardiopulmonary resuscitation in critically ill adults with coronavirus disease 2019 (covid-19).
Design: Multicenter cohort study.
Setting: Intensive care units at 68 geographically diverse hospitals across the United States.
Article Synopsis
- AKI (acute kidney injury) is common in COVID-19 patients, and the role of the soluble urokinase plasminogen activator receptor (suPAR) in this condition is being investigated as a potential risk factor.
- In a study involving 352 hospitalized COVID-19 patients, higher suPAR levels were linked to a significantly increased risk of developing AKI and the need for dialysis.
- The findings suggest that monitoring suPAR levels at admission could help predict AKI outcomes in hospitalized COVID-19 patients, indicating its potential role in the disease's kidney-related complications.
Purpose: To report 4 previously undescribed postoperative complications in 4 cases of ab interno XEN45 Gel Stent (XEN) implantation following uncomplicated surgeries.
Patients And Methods: A total of 51 consecutive XEN implantations performed between July 1, 2017 and April 30, 2018 were reviewed. All cases were performed by 7 experienced glaucoma surgeons affiliated with the William Beaumont Hospital, Department of Ophthalmology.