Publications by authors named "Husam Abdoh"
Background: Patients with hematological cancers have increased COVID-19 morbidity and mortality, and these patients show attenuated vaccine responses. This study aimed to characterize the longitudinal humoral immune responses to COVID-19 vaccination in patients with hematological malignancies.
Patients And Methods: We conducted a prospective cohort study, collecting samples from March 2021 to July 2022, from patients seen at a cancer treatment center in London, Ontario, Canada, who met the following eligibility criteria: age ≥18 years, diagnosed with a hematological malignancy, recipient of a COVID-19 vaccine during the study period, and able to provide informed consent.
Article Synopsis
- * This test showed 100% specificity and about 98% sensitivity when validating it with blood plasma samples, effectively identifying antibodies related to the virus.
- * Our findings indicate that over 92% of patients had detectable antibodies on the same day they tested positive for the virus, suggesting this test could enhance diagnosis when used alongside traditional RNA testing.
Article Synopsis
- Researchers explored how humoral immunity works in COVID-19 by analyzing plasma samples from 146 patients to better understand antibody responses against the virus.
- They developed a high-resolution method using peptide microarrays that identified specific epitopes within the spike and nucleocapsid proteins and correlated these with clinical outcomes.
- This advanced testing approach may improve predictions of patient survival and differentiate between types of antibodies, helping to track responses to virus variants.