Dextrose 50% versus Dextrose 10% or Dextrose Titration for the Treatment of Out-of-Hospital Hypoglycemia: A Systematic Review.

Introduction: Paramedics commonly administer intravenous (IV) dextrose to severely hypoglycemic patients. Typically, the treatment provided is a 25g ampule of 50% dextrose (D50). This dose of D50 is meant to ensure a return to consciousness.

Améliorer le rappel des individus âgés de 60 ans et plus à l'aide de l'entretien cognitif : une revue et méta-analyse.

Les aînés sont souvent perçus comme des témoins peu fiables, une perception qui est partiellement appuyée par des travaux qui démontrent que les témoignages des aînés tendent à être moins détaillés que ceux produits par des témoins plus jeunes. L'entretien cognitif est une technique d'interrogatoire qui repose sur des stratégies de rappel issues des sciences cognitives. Plusieurs travaux récents démontrent l'efficacité de l'entretien cognitif auprès d'échantillons de jeunes adultes.

Comparative multiplex dosage analysis detects whole exon deletions at the phenylalanine hydroxylase locus.

We have developed quantitative comparative multiplex dosage analysis to detect altered copy number of regions of the phenylalanine hydroxylase gene. Out of 41 alleles (4% of 1,010 PKU chromosomes) on which a mutation had not been characterized previously, this technique has highlighted two novel mutations: deletions of exon 5 and of exon 6 on a total of eight alleles. Restriction-enzyme digestion of genomic DNA and hybridization to an amplified segment of the phenylalanine hydroxylase (PAH) cDNA probe PAH247 established the size of the deletion in five individuals to be between 700 and 900 bases.

PAHdb 2003: what a locus-specific knowledgebase can do.

PAHdb, a legacy of and resource in genetics, is a relational locus-specific database (http://www.pahdb.mcgill.

alphaNAC requires an interaction with c-Jun to exert its transcriptional coactivation.

alphaNAC is a transcriptional coactivator known to interact with the N-terminal activation domain of the c-Jun transcription factor. In this article, we describe the identification of the c-Jun interaction domain within the alphaNAC protein. Deletion analysis of alphaNAC indicated that the c-Jun binding site was located in the middle part of the protein, between residues 89 and 129.

Etoposide combined with cyclophosphamide plus vincristine compared with doxorubicin plus cyclophosphamide plus vincristine and with high-dose cyclophosphamide plus vincristine in the treatment of small-cell carcinoma of the lung: a randomized trial of the Bristol Lung Cancer Study Group.

A total of 353 patients with previously untreated small-cell lung cancer (SCLC) were accrued in this multicenter trial. Patients were randomly assigned to receive one of the following three regimens: cyclophosphamide 1,000 mg/m2 intravenously (IV) day 1, vincristine 1.4 mg/m2 IV day 1, and etoposide 50 mg/m2 IV day 1, followed by etoposide 100 mg/m2/day orally days 2 through 5 (CEV); cyclophosphamide 1,000 mg/m2 IV day 1, vincristine 1.

Retropneumoperitoneum and pneumatosis intestinalis in 2 patients with mixed connective tissue disease and the overlap syndrome.

Two patients with pneumatosis intestinalis (PI) and mixed connective tissue disease/overlap syndrome are discussed. One patient also presented a retropneumoperitoneum, a feature as yet undescribed in PI. A review of previously reported cases revealed that PI should be suspected in those patients known to have systemic sclerosis-type involvement of the oesophagus and the small bowel, and who present with abdominal distension.

[Small-cell carcinoma ("oat cell" carcinoma) of the esophagus, a rare lesion: report of 2 new cases].

Small cell ("oat cell") carcinoma of the esophagus is a rare disease: only seventy-four patients have been reported in the world literature. We add two new patients, one of whom was studied radiologically. Since oat cell carcinoma originates from the neuro-ectoderm, it is not surprising to see such examples arising outside the lung and in particular from the digestive tract.

Remission from central nervous system involvement in adults with acute leukemia. Effect of intensive therapy and prognostic factors.

Eighty-seven adult patients who had achieved bone marrow remission of leukemia developed one or more episodes of meningeal leukemia. Multiple patient characteristics were examined for their effect on probability of achieving complete remission from meningeal disease and for their effect on duration of meningeal remission. Presence of obtundation (P less than 0.

[Predictive value of preoperative acidity tests in ulcer recurrence after supraselective vagotomy].

The authors have analysed the predictive value of the basal and peak gastric acidity levels, measured preoperatively, in a series of 27 supraselective vagotomies. They recommend care in the choice of this operation for hypersecretors and they propose criteria for the preoperative selection of the candidates. They suggest determination of the preoperative basal gastric acidity level and a cimetidine suppression test to identify patients at high risk for recurrence of the ulcer.

An unusual case of primary arteriocolic fistula.

A case is presented of lower digestive bleeding, caused by a fistula between a right iliac artery aneurysm and the sigmoid colon. Particular aspects of this unusual fistula are discussed from a diagnostic and therapeutic point of view.

Restoring patency of occluded central venous catheters.

Thrombotic occlusion remains a major cause of central venous catheter removal prior to completion of therapy. Injection of a dilute solution of a potent fibrinolytic agent, urokinase or streptokinase, into the occluded Silastic central venous catheter consistently reestablishes its patency. This procedure was performed on 352 occluded silicone elastomer central venous catheters with only one failure and one minor complication.