": The Epidemiology of Toxigenic Strains in the Antibiotic Era-Insights from a Prospective Study at a Regional Infectious Diseases Hospital in Eastern Europe.

infection (CDI), though identified nearly five decades ago, still remains a major challenge, being associated with significant mortality rates. The strains classified as hypervirulent, notably 027/NAP1/BI, have garnered substantial attention from researchers and clinicians due to their direct correlation with the severity of the disease. Our study aims to elucidate the significance of toxigenic (CD) strains in the clinical and therapeutic aspects of managing patients diagnosed with CDI.

Differential Protective Effect of Zinc and Magnesium for the Hepatic and Renal Toxicity Induced by Acetaminophen and Potentiated with Ciprofloxacin in Rats.

: The purpose of this study was to investigate the influence induced by magnesium chloride (MgCl) and zinc gluconate (ZnG) supplementation on liver and kidney injuries experimentally induced with acetaminophen (AAPh) and potentiated by a ciprofloxacin addition in rats. : The experiment was performed on five animal groups: group 1-control, treated for 6 weeks with normal saline, 1 mL/kg; group 2-AAPh, treated for 6 weeks with AAPh, 100 mg/kg/day; group 3-AAPh + C, treated for 6 weeks with AAPh 100 mg/kg/day and ciprofloxacin 50 mg/kg/day, only in the last 14 days of the experiment; group 4-AAPh + C + Mg, with the same treatment as group 3, but in the last 14 days, MgCl 10 mg/ kg/day was added; and group 5-AAPh + C + Zn, with the same treatment as group 3, but in the last 14 days, zinc gluconate (ZnG), 10 mg/kg/day was added. All administrations were performed by oral gavage.

Tuberculous Meningitis in Children and Adults: A 10-Year Retrospective Comparative Analysis.

Background: Tuberculous meningitis (TBM) is the most lethal form of Mycobacterium tuberculosis infection, which has a high rate of neurological complications and sequelae.

Objectives: Our study offers a real-world infectious disease clinic perspective, being thus representative for the clinical environment of developing countries.

Methods: We performed a retrospective analysis of the 127 adult and 77 pediatric cases diagnosed with TBM in the Infectious Disease Hospital of the School of Medicine of Iasi, Romania between 2004-2013.

Tuberculosis meningo-encephalitis with positive csf for KB and slowly favourable evolution. Case report.

Background: Meningoencephalitis produce by Koch bacillus is a disease including various symptoms, with often atypical onset and evolution, and with an etiological diagnosis being rarely established. It therefore remains a disease with severe prognosis, despite adequate treatment.

Case Report: a 47 years old male from Neamt County, with chronic otitis in his recent medical history, comes to the emergency room for fever, severe headache, confusion, equilibrium disorders, influenced health status, and meningeal irritation signs.

Tuberculous meningitis--clinical and epidemiological considerations (a retrospective study 2008-2011).

Unlabelled: Tuberculous meningitis represents one of the most severe forms of tuberculosis and is often a difficult diagnostic and therapeutic problem. The objective of this study is to analyze the cases of tuberculous meningitis in our region.

Material And Methods: We retrospectively analyzed 76 observation sheets of patients aged 4 months to 84 years, diagnosed with tuberculous meningitis, admitted to Infectious Diseases Hospital Iaşi during 2008 to 2011.

[Prognostic score in infective endocarditis--innovative and useful predictibility factor for disease's evolution].

Aim: Evaluate the potential of evolution in infective endocarditis (IE) according to patient's personal parameters (biological, clinical and paraclinical), and Carmeli score, as purpose in establishing an appropiate antibiotherapy.

Material And Methods: Clinico-therapeutic observations concerning a cohort of 868 patients admitted between 1995 and 2008 in three hospital services of Iaşi. The following guide marks were included in the study: age, sex, previous state of heart, left/right sided IE, number of valves implicated, presence of major complications, health care associated IE/nosocomial IE, major associated diseases, type of microorganism implicated/negative blood cultures.

[Community acquired acute bacterial meningitis--a 10 year review].

Unlabelled: Bacterial meningitis is still an important topic for the infectious diseases specialist, due to it's high incidence, severity and it's high mortality rate.

Material And Method: We retrospectively studied 679 patients diagnosed with community acquired bacterial meningitis in the Infectious Diseases Hospital Iaşi, Romania between 1998 and 2007.

Results: The annual number of admissions slightly decreased in the last years.

[Leptospirosis in children. Clinico-biological and therapeutic aspects for the cases hospitalised between 1992-2005].

Unlabelled: The aim of the study is that of showing the prevalence of the disease in childhood in our county.

Material And Method: We studied the observation files of the patients admitted in our unit in between 1992 and 2005 comprised in the 0-15 year old age bracket, noticing all the epidemiological, clinical and therapeutic aspects.

Results: In the above mentioned period, 16 patients from the 0-15 year old group (3.

[Epidemiology of viral hepatitis B in the Iasi County in the interval 1990-2005].

Viral hepatitis and especially hepatitis B (HVB) continue to represent major health problems. In Romania, the morbidity from HVB is still 3 to 5 times higher than in Western Europe and North America. In the Iasi County, the effectiveness of the preventive measures is proven by a curve of morbidity values close to or even below those recorded at national level.

[The co-infection with hepatitis virus B and D--cases admitted in the infectious diseases hospital from Iaşi, Romania (2003-2005)].

Despite the major medical advance, over 350 million people worldwide still have chronic infection with hepatitis B virus and HBV-associated liver disease remains a major cause of morbidity and mortality. 15-50% of patient VHB infected have serological markers for VHD co-infection. We retrospectively studied 252 cases of acute hepatitis B (AHB) admitted in our hospital between 2003-2005; 12 of them (4.

[Varicella-zoster infection--extreme clinical aspects].

Unlabelled: Infections with the varicella-zoster (VZ) virus are a constant of our everyday practice. The aim of the present study is that of underlining unusual aspects of the infection with the VZ virus--primary infection in adults and herpes zoster in children. If varicella, or chickenpox, has been traditionally considered a childhood disease, nowadays, an increased number of adults are affected by primary infections.

[Epidemiologic and clinical aspects of acute hepatitis B in the past decade].

To study the clinical and epidemiological aspects of acute B hepatitis during the last 11 years. We retrospectively studied 1712 patient files, admitted in the Department of Infectious Diseases Iaşi, with acute B hepatitis between 1992-2002. The majority of the patients (69%) had an urban origin.

[Clinical and biological study of acute diarrhea with mixed etiology in 48 patients].

Objectives: The study of incidence, clinical manifestation and treatment of acute diarrhea with mixed etiology.

Material And Method: Study of 48 patients with acute diarrhea with mixed etiology admitted in the Hospital of Infectious Diseases of Iaşi during 1995-1998.

Results: 12 cases (24%) were mixed bacterial infections with the following microorganisms associations: Salmonella + Shigella (10 cazuri); Salmonella + Yersinia enterocolitica (1 case); Salmonella + Rotavirus (1 case).

[Postoperative and posttraumatic meningitis. Comments on 87 cases].

Iatrogenic and traumatic cerebromeningitis infections are increasing in frequency in the last two decades. Retrospective analysis of 87 patients iatrogenic and traumatic bacterial meningitis were admitted in the Clinic of Infectious Diseases from Iaşi between 1, 01, 1990-31, 12, 1994. Head trauma, lumbar punctures and iatrogenic meningitis infections were the causes cerebromeningitis infections.

[The streptococcal and staphylococcal toxic shock syndrome. Comments on 4 cases].

Between 1989 and 1995 in the Hospital of Infectious Diseases from Iaşi have been diagnoses 4 cases of streptococcal/staphylococcal toxic syndrome. Three patients have been grown up and one child. Two of them were immunocompromised hosts (cirrhosis, lung tuberculosis, alcoholism).

[The effect of cardioversion in sinus rhythm on the systolic dynamics in atrial fibrillation and flutter].

In 60 cases of atrial fibrillation and flutter the systolic time intervals, haemodynamic ratios (PEj/PPE, PPE/PEj and PEj/TCIV) and ejection fraction before and after cardioversion in sinus rhythm were determined. The cardiac performance was markedly improved in all cases regardless the etiology and the degree of ventricular efficiency, pleading for the use of cardioversion anytime there is a chance to restore and maintain the sinus rhythm. The persistence of anticreased venous pressure, as well as the absence or late resumption of atrial mechanic activity usually indicate that arrhythmia soon recurs.