Drug Repurposing of FDA Compounds against α-Glucosidase for the Treatment of Type 2 Diabetes: Insights from Molecular Docking and Molecular Dynamics Simulations.

Type 2 diabetes mellitus is a chronic health problem that can be controlled by slowing one's carbohydrate metabolism by inhibiting α-glucosidase, an enzyme responsible for carbohydrate degradation. Currently, drugs for type 2 diabetes have limitations in terms of safety, efficiency, and potency, while cases are rapidly increasing. For this reason, the study planned and moved towards drug repurposing by utilizing food and drug administration (FDA)-approved drugs against α-glucosidase, and investigated the molecular mechanisms.

Self-assembly, optical, thermal and electrochemical properties of bis-N-benzyl perylene diimide dye.

Flexible methylene containing N,N'-bis-(benzyl)-3,4,9,10-perylenebis(dicarboximide) (1) was synthesized. Self-assembled microstructures (hollow tubes, average length and width: 7.7 and 0.

Synthesis of a novel fluorescent amphiphilic chitosan biopolymer: photophysical and electrochemical behavior.

The present investigation describes for the first time, the synthesis and detailed characterization of a novel fluorescent and amphiphilic chitosan polymer (3) containing fluorescent peryleneimide chromophores for biomedical applications. The polymer 3 is moderately soluble in a wide range of organic solvents and aqueous solutions, unlike chitosan (2). The Mw of 3 and 2 determined by GPC were 467 kDa and 460 kDa, respectively.

A new tunable light-emitting and π-stacked hexa-ethyleneglycol naphthalene-bisimide oligomer: synthesis, photophysics and electrochemical properties.

An oligomer (3) containing flexible hydrophilic hexa(ethylene glycol) and hydrophobic naphthalene-bisimide chromophores has been synthesized by a one-step condensation reaction and its photophysical and electrochemical properties were investigated. 3 was characterized through the data from NMR, IR, UV-vis, GPC, DSC, TGA, elemental analysis and cyclic voltammetry. The average molecular weight (M(w)) of 3 was 4430 g mol(-1).

Chiral substituent containing perylene monoanhydride monoimide and its highly soluble symmetrical diimide: synthesis, photophysics and electrochemistry from dilute solution to solid state.

A new chiral perylene monoanhydride monoimide (1) with a sterically hindered chiral amine was successfully synthesized for further selective functionalization at terminal positions. At the same time, the chiral perylene diimide (2) with the same amine has been synthesized. The synthesized products were characterized using the data from NMR, IR, MS, UV-vis, DSC, TGA, elemental analysis and cyclic and square wave voltammetry.

Novel naphthalene diimides and a cyclophane thereof: synthesis, characterization, photophysical and electrochemical properties.

Three novel naphthalene diimides (1-3) and a cyclophane (4) containing two naphthalene diimide moieties were synthesized and characterized. In contrast to the absorption spectra, the emission spectra were strongly dependent on the solvent polarity. The excimer-like emission and low fluorescence rate constant suggest the formation of ground state complexes in DMF.