Publications by authors named "Hurabielle C"
Background: Systemic lupus erythematosus (SLE) has numerous symptoms across organs and an unpredictable flare-remittance pattern. This has made it challenging to understand drivers of long-term SLE outcomes. Our objective was to identify whether changes in DNA methylation over time, in an actively flaring SLE cohort, were associated with remission and whether these changes meaningfully subtype SLE patients.
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- Vitamin B12 is essential for blood cell formation and nerve insulation, and its deficiency can lead to neurological issues despite normal blood levels, as seen in a patient with symptoms like tremor and cognitive decline.
- Researchers discovered an autoantibody against the transcobalamin receptor (CD320) that hinders vitamin B12 uptake in the brain, resulting in low levels found in cerebrospinal fluid even when blood levels appear normal.
- The study suggests this autoimmune condition can be treated with immunosuppressive therapy and high-dose vitamin B12, and highlights the importance of recognizing how B12 transport differs in various tissues, which could improve diagnosis and treatment strategies for similar neurological disorders.
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- Inborn errors of immunity (IEI) are a group of 485 disorders identified in 2022, highlighting genetic causes and their relevance in various immune-related conditions.
- Recent advancements in genomic technologies have accelerated the discovery of IEI and contributed to the development of new treatment strategies.
- This review will focus on the complexities of IEI, including the differences between primary immunodeficiencies (PIDD) and primary immune regulatory disorders (PIRD), Mendelian inheritance patterns, and the role of functional genomics in better understanding and treating these disorders.
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- Multisystem inflammatory syndrome in adults (MIS-A) is a serious condition linked to COVID-19 that can cause severe health issues and higher mortality rates.* -
- Three cases of MIS-A were analyzed, revealing symptoms like cardiogenic shock and high inflammatory markers, with one patient also developing Type 1 diabetes and sepsis.* -
- All patients recovered fully with standard treatments and immunotherapy, highlighting the importance of early detection and intervention for effective management of MIS-A symptoms.*
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- Candida auris is a dangerous fungal pathogen that is resistant to multiple drugs, often colonizing patients' skin and leading to hospital outbreaks.
- Researchers created a mouse model to study how C. auris colonizes the skin and to evaluate potential protective measures for patients.
- Findings indicate that certain immune responses can help prevent long-term colonization and that chlorhexidine antiseptic can effectively reduce C. auris presence, aiding in the development of strategies to tackle its global spread.
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- Kikuchi-Fujimoto disease (KFD) is a self-limiting condition causing lymphadenitis, and a similar pattern called "Kikuchi disease-like inflammatory pattern" (KLIP) has been noted in skin lesions, potentially indicating lupus.
- A study compared 13 lupus patients with KLIP to 39 control lupus patients without KLIP, finding a higher prevalence of systemic lupus erythematosus (SLE) and severe disease in those with KLIP.
- Treatment with thalidomide showed effective results in clearing skin lesions for KLIP patients, highlighting the need for close monitoring in patients at risk of developing severe SLE.
Effect of Ruxolitinib on Lung Function after Allogeneic Stem Cell Transplantation.
Biol Blood Marrow Transplant
November 2020
Article Synopsis
- * A study involving 70 patients assessed the impact of ruxolitinib on lung function, specifically looking at parameters like forced expiratory volume (FEV) and forced vital capacity (FVC).
- * Results indicated that ruxolitinib did not improve lung function over time, with FEV decreasing significantly regardless of whether patients received the treatment or not.
Immunity to commensal skin fungi promotes psoriasiform skin inflammation.
Proc Natl Acad Sci U S A
July 2020
Article Synopsis
- The immune system is always prepared to recognize and respond to the microbiota, which includes a preexisting pool of T cells specific to these microorganisms, even before any inflammatory trigger occurs.
- In a study using a psoriasis model, exposure to certain commensal skin fungi was found to worsen tissue inflammation due to pre-formed T cell responses.
- The increased inflammation linked to fungal exposure involves specific immune mechanisms (Th17 responses and neutrophil traps) and shares similarities with the gene expression patterns seen in human psoriasis-affected skin.
The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with the development of organized cellular clusters within the skin epithelium.
View Article and Find Full Text PDFBackground: While some information on psoriasis impact on pregnancy is available, very little is known on the preoccupations of women afflicted by the disease or on the dermatologists' (D) positioning as to psoriasis and pregnancy. The 'Objectifs Peau' project demonstrated a 4.7% prevalence of psoriasis in women aged 18-45 years in France.
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- Barrier tissues, like the skin, are important for immune defense and contain many immune cells called commensal-specific T cells, which respond to environmental stressors.
- These skin-resident T cells exhibit a unique dual program that allows them to quickly switch to a tissue-repairing mode when faced with injury or inflammation.
- However, if the immune regulation is disrupted, these T cells can also trigger harmful overreactions, highlighting their role in balancing local immunity and tissue healing.
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- Periodontitis is a common inflammatory disease, and this study reveals a significant increase in resident memory T helper 17 (T17) cells in affected individuals, indicating a potential area for therapeutic targeting.
- T17 cell expansion in periodontitis is linked to a dysbiotic microbiome and relies on two cytokines, IL-6 and IL-23, unlike the T17 cells that maintain oral health.
- The research suggests that targeting T17 cell differentiation may offer new ways to treat periodontitis, as observed in both experimental models and in patients with a genetic defect affecting T17 cells, leading to reduced inflammation despite a higher risk of fungal infections.
Introduction: Adult T-cell leukemia/lymphoma (ATLL) is a hematological malignancy associated with chronic HTLV-1 infection.
Aim: To describe skin lesions in ATLL.
Methods: A descriptive, retrospective study between 1996 and 2016, including all patients diagnosed with ATLL at Saint-Louis Hospital (Paris, France).
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- Eruption of lymphocyte recovery (ELR) can happen after chemotherapy when bone marrow activity is low, and this study looked at 12 patients who showed unusual skin problems that looked like a disease called T-cell lymphoma.
- All the patients had a reddish skin rash and fever, and most had received chemotherapy for blood cancer or bladder cancer before the rash appeared.
- Skin tests showed special T cells that were very active, and some doctors thought it might be a different illness, but it turned out to be ELR with these unique skin symptoms, so doctors need to know about this to avoid confusion.
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- The study aimed to evaluate the effectiveness of nailfold videocapillaroscopy (NVC) in detecting microvascular changes in patients with systemic sclerosis (SSc) and its correlation with disease progression and organ damage.
- A cohort of 140 SSc patients was followed for three years, with NVC assessments conducted annually; significant changes were noted in 51% of patients, with loss of capillaries linked to disease progression and new digital ulcers.
- The research concluded that NVC is a valuable tool for monitoring SSc, as the loss of capillaries can serve as a reliable indicator of disease progression.
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- KIR3DL2 is identified as a crucial marker for detecting malignant T cells in Sézary syndrome, showing high sensitivity as a diagnostic tool compared to traditional methods.
- In a study with 64 patients, high levels of KIR3DL2 and eosinophil counts were linked to poorer survival outcomes, highlighting its importance in prognosis.
- KIR3DL2 not only aids in diagnosis but also helps monitor treatment effectiveness and detects disease relapse, making it a valuable resource in managing Sézary syndrome routinely.
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- * Among 70 patients, 97% experienced a significant rise in creatinine levels after starting Vemurafenib, but levels returned to normal after discontinuation in most cases.
- * The increase in creatinine was linked to both the inhibition of creatinine tubular secretion and some impairment of renal function, but since this increase is usually reversible, treatment should not be stopped if Vemurafenib is effective.
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- The study investigates the relationship between cutaneous telangiectasia (CT) occurrences in systemic sclerosis (SSc) patients and their potential to indicate vascular disease severity.
- It includes 87 SSc patients, revealing that both profuse and pseudotumoral CT correlate with severe patterns in microvascular lesions and are associated with conditions like digital ulcers and pulmonary hypertension.
- The findings suggest that the number and size of CT could be meaningful indicators for assessing vascular disease severity in SSc, warranting further research to explore their potential as early clinical biomarkers.