One-step synthesis of Janus hydrogel via heterogeneous distribution of sodium α-linoleate driven by surfactant self-aggregation.

Janus adhesive hydrogels have one-sided adhesive properties and hold promising applications in the health care field. However, a simple method for synthesizing Janus hydrogels is still lacking. In this study, we introduce an innovative method to prepare Janus hydrogels by harnessing a fundamental phenomenon: the self-aggregation of surfactants at high concentrations at the water-air interface.

Target Profiling of an Iridium(III)-Based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP.

Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic cell death (ICD), representing a "second hit" from the host immune system to tumor cells. Although chemo-immunotherapy is highly promising, ICD inducers remain sparse with vague drug-target mechanisms.

Identification of an Au(I) N-Heterocyclic Carbene Compound as a Bactericidal Agent Against .

The opportunistic pathogen () causes infections that are difficult to treat, which is due to the bacterial resistance to antibiotics. We herein identify a gold(I) N-heterocyclic carbene compound as a highly potent antibacterial agent towards . The compound significantly attenuates virulence and leads to low tendency to develop bacterial resistance.