Background: The impact of blood-brain barrier (BBB) leakage on white matter hyperintensity (WMH) subtypes (location) and its association with clinical factors and cognition remains unclear.
Purpose: To investigate the relationship between WMH volume, permeability, clinical factors, and cognition in older individuals across the cognitive spectrum.
Study Type: Prospective, cross-sectional.
Background: Dual-energy (DE) chest radiography (CXR) enables the selective imaging of two relevant materials, namely, soft tissue and bone structures, to better characterize various chest pathologies (i.e., lung nodule, bony lesions, etc.
View Article and Find Full Text PDFComput Methods Programs Biomed
November 2017
Background And Objective: Digital tomosynthesis (DTS) based on filtered-backprojection (FBP) reconstruction requires a full field-of-view (FOV) scan and relatively dense projections, which results in high doses for medical imaging purposes. To overcome these difficulties, we investigated region-of-interest (ROI) or interior DTS reconstruction where the x-ray beam span covers only a small ROI containing a target area.
Methods: An iterative method based on compressed-sensing (CS) scheme was compared with the FBP-based algorithm for ROI-DTS reconstruction.
Here we report on the development and validation of a sensitive and rapid reversed-phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of propiverine in human plasma. After adding an internal standard (oxybutynin chloride) to human plasma, samples were extracted using n-hexane/ethylacetate (8:2, v/v). Compounds extracted were analyzed by reversed-phase high-performance liquid chromatography (HPLC) with multiple reaction monitoring (MRM) mode for analyte detection.
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