Volume and Permeability of White Matter Hyperintensity on Cognition: A DCE Imaging Study of an Older Cohort With and Without Cognitive Impairment.

Background: The impact of blood-brain barrier (BBB) leakage on white matter hyperintensity (WMH) subtypes (location) and its association with clinical factors and cognition remains unclear.

Purpose: To investigate the relationship between WMH volume, permeability, clinical factors, and cognition in older individuals across the cognitive spectrum.

Study Type: Prospective, cross-sectional.

Framework for dual-energy-like chest radiography image synthesis from single-energy computed tomography based on cycle-consistent generative adversarial network.

Background: Dual-energy (DE) chest radiography (CXR) enables the selective imaging of two relevant materials, namely, soft tissue and bone structures, to better characterize various chest pathologies (i.e., lung nodule, bony lesions, etc.

Image reconstruction in region-of-interest (or interior) digital tomosynthesis (DTS) based on compressed-sensing (CS).

Background And Objective: Digital tomosynthesis (DTS) based on filtered-backprojection (FBP) reconstruction requires a full field-of-view (FOV) scan and relatively dense projections, which results in high doses for medical imaging purposes. To overcome these difficulties, we investigated region-of-interest (ROI) or interior DTS reconstruction where the x-ray beam span covers only a small ROI containing a target area.

Methods: An iterative method based on compressed-sensing (CS) scheme was compared with the FBP-based algorithm for ROI-DTS reconstruction.

Quantification of propiverine by liquid chromatography/electrospray tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy subjects.

Here we report on the development and validation of a sensitive and rapid reversed-phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of propiverine in human plasma. After adding an internal standard (oxybutynin chloride) to human plasma, samples were extracted using n-hexane/ethylacetate (8:2, v/v). Compounds extracted were analyzed by reversed-phase high-performance liquid chromatography (HPLC) with multiple reaction monitoring (MRM) mode for analyte detection.