Publications by authors named "Hunter T Holloway"
Subtle behavioral and cognitive deficits have been documented in patient cohorts with orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated with structural brain abnormalities but have been limited to adolescent and adult populations where brain plasticity during infancy and childhood may be a confounding factor. Here, we employed high resolution magnetic resonance microscopy to examine primary brain morphology in a mouse model of OFCs.
View Article and Find Full Text PDFAnimal model-based studies have shown that ethanol exposure during early gestation induces developmental stage-specific abnormalities of the face and brain. The exposure time-dependent variability in ethanol's teratogenic outcomes is expected to contribute significantly to the wide spectrum of effects observed in humans with fetal alcohol spectrum disorder (FASD). The work presented here employs a mouse FASD model and magnetic resonance microscopy (MRM; high resolution magnetic resonance imaging) in studies designed to further our understanding of the developmental stage-specific defects of the brain that are induced by ethanol.
View Article and Find Full Text PDFArticle Synopsis
- Prenatal ethanol exposure is the top preventable cause of congenital mental disabilities, but many affected individuals don't show the classic facial traits of fetal alcohol syndrome (FAS).
- A study used MRI and shape analysis to investigate how ethanol exposure at different stages of pregnancy affects both facial and brain development in mouse fetuses, revealing distinct facial characteristics and brain abnormalities for each stage.
- Early exposure on gestational day 7 led to severe facial dysmorphology similar to human FAS, while exposure on day 8.5 resulted in milder features; this indicates the need to broaden diagnostic criteria for fetal alcohol spectrum disorders to identify varying defect patterns.