A review of fenfluramine for the treatment of Dravet syndrome patients.

Introduction: Dravet Syndrome (DS) is a rare epileptiform disorder typically presenting within the first year of life of a normally developing infant. It is characterized by several prolonged seizures that are often resistant to current anti-epileptic drug (AED) regimens. This paper outlines the history and clinical trials of the drug fenfluramine, a drug that when used in addition to AED regimens may provide hope to children affected by DS.

Clinical experience with maintenance therapeutic plasma exchange in refractory generalized myasthenia gravis.

Background: Despite the availability of several immunomodulatory therapies, about 20% of myasthenia gravis (MG) patients remain refractory to conventional treatments. There is limited evidence to support the use of maintenance therapeutic plasma exchange (TPE) therapy for refractory generalized MG.

Methods: Retrospective chart review of 14 patients with refractory generalized MG treated for 12 months with maintenance TPE therapy.