Publications by authors named "Hunter G Lindsay"

Neuroinflammation is associated with several neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Neuroinflammation provides protection in acute situations but results in significant damage to the nervous system if chronic. Overexpression of chemokines within the brain results in the recruitment and activation of glial and peripheral immune cells which can propagate a cascading inflammatory response, resulting in neurodegeneration and the onset of neurodegenerative disorders.

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Cancer-associated fibroblasts (CAFs) are integral to the solid tumor microenvironment. CAFs were once thought to be a relatively uniform population of matrix-producing cells, but single-cell RNA sequencing has revealed diverse CAF phenotypes. Here, we further probed CAF heterogeneity with a comprehensive multiomics approach.

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Introduction: Smoking cessation counseling is a central part of the Medicare guidelines for lung cancer screening. With increasing age, many heavy smokers eventually stop smoking, however, factors influencing the decision to stop smoking are poorly understood. We postulated that declining health or physician-diagnosis of a medical condition may be associated with successful smoking cessation.

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Article Synopsis
  • Biofilm-associated infections in orthopedic surgery can lead to severe clinical complications and challenges in diagnosis, often resulting in ineffective antibiotic treatments due to bacteria's protective structures.
  • Researchers explored the effects of a compound called MnTE-2-PyP, which is known to scavenge reactive species and modify the redox state, in treating these infections.
  • In tests on a mouse model, combining MnTE-2-PyP with antibiotics significantly reduced bacterial counts in infected bone compared to antibiotics alone, suggesting that managing the redox environment can enhance antibiotic efficacy against biofilm-related infections.
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