Publications by authors named "Hunter Chung"
Article Synopsis
- - Cytosine methylation is a key epigenetic modification in DNA that influences normal physiology and diseases, but its relationship with sex differences has been underexplored.
- - Analysis of DNA methylation in various tissues from male and female mice revealed significant sexual dimorphism, with numerous loci exhibiting differences primarily driven by higher methylation levels in females, independent of testosterone in some cases.
- - The study suggests that sex influences epigenetic states in a tissue-specific manner, which could have important implications for understanding differences in health and disease between genders.
DNA methylation is essential for mammalian development and physiology. Here we report that the developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S-adenosylhomocysteine (SAH). SAH is a potent feedback inhibitor of S-adenosylmethionine (SAM)-dependent methyltransferases that methylate diverse cellular components, including DNA, RNA, proteins, lipids and neurotransmitters.
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