Publications by authors named "Hunter C Russell"
Article Synopsis
- Cancer involves changes in how certain genes are turned on or off, and researchers found areas in DNA that are less active (hypomethylated) from early cancer stages to when it spreads.
- They discovered 40 key areas in the DNA that remain less active while some other smaller areas that help cells grow are still active.
- Some of the turned-off genes are important for the immune system, and turning them back on in mice can stop tumor growth and boost the immune response against cancer.
Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterization using mouse melanoma models, we show that the KEAP1/NRF2 pathway modulates sensitivity to ICB, independently of tumorigenesis. The NRF2 negative regulator, KEAP1, shows intrinsic variation in expression, leading to tumor heterogeneity and subclonal resistance.
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