Post-acute COVID and long-COVID among adults and older adults in the State of Paraná, Brazil: protocol for an ambispective cohort study.

Introduction: Since 2020, the world has been going through a viral pandemic with a high morbidity and mortality rate along with the potential to evolve from an acute infection to post-acute and long-COVID, which is still in the process of elucidation. Diagnostic and prognostic research is essential to understand the complexity of factors and contexts involving the illness's process. This protocol introduces a study strategy to analyse predictors, sequelae, and repercussions of COVID-19 in adults and older adults with different disease severities in the State of Paraná, Brazil.

Serous retinal detachment as an Early manifestation of lúpus choroidopathy.

Serous retinal detachment can be caused by a wide range of conditions, including systemic lupus erythematosus. Although this association has been well-described in patients with an established diagnosis of systemic lupus erythematosus, in rare cases, this detachment is the initial manifestation. We have described here an unusually challenging case in which serous retinal detachment required a comprehensive investigation considering that it was an early sign of systemic lupus erythematosus.

Cross-cultural adaptation and content validity of leisure attitude measurement for older adults.

Objective: To adapt the Leisure Attitude Measurement to the Brazilian culture and to evaluate the face and content validity of the Brazilian version for older population.

Methods: Methodological study of cross-cultural adaptation in five stages: initial translation; synthesis of translations; back translation; evaluation by a committee of experts using a face and content validity assessment instrument; pre-test with 36 elderly, selected by convenience, with the application of a pre-test evaluation instrument. Data were analyzed descriptively and internal consistency measured by Cronbach's alpha coefficient.

Homeless population: characterization and contextualization by census research.

Objectives: to analyze characteristics of homeless people and factors associated with living on the streets.

Methods: a census-type sectional survey carried out between 2015 and 2018, in the municipality of Maringá-Paraná. A total of 701 homeless answered a structured questionnaire with sociodemographic data, living conditions, and drug use.

Drug use by men admitted to a psychiatric hospital.

Objective: to assess risk related to drug use in men admitted to a psychiatric hospital and to identify associations with sociodemographic, socioeconomic variables, and risk conditions.

Method: a cross-sectional study with the application of a screening test in 209 participants hospitalized for mental and behavioral disorders due to the use of psychoactive substances. Statistical analysis was performed using descriptive statistics and adjustment of a binary logistic regression model for moderate or high risk of drug use.

Thermoregulatory profile of neurodegeneration-induced dementia of the Alzheimer's type using intracerebroventricular streptozotocin in rats.

Aim: Here, we have extensively investigated the relationship between thermoregulation and neurodegeneration-induced dementia of the Alzheimer's type using intracerebroventricular injections of streptozotocin (icv-STZ).

Methods: Male Wistar rats were treated with bilateral injections of icv-STZ, and their thermoregulatory profiles (core body temperature, tail-skin temperature, cold and heat defence responses and thermal place preference) were evaluated. Spatial memory, locomotor activity, social interaction, brain ventricular volume, and Aβ and tau protein levels in the brain were analysed to characterize the effects of STZ on the brain and behaviour.