Publications by authors named "Hung-Liang Pai"
Triple-negative breast cancer (TNBC) represents a challenging malignancy with limited treatment options and a poor prognosis. Adjuvant therapies, including chemotherapy and immune checkpoint inhibitors (ICI), are commonly employed following breast conservation surgery. However, these treatments can lead to various adverse effects, including cutaneous complications and connective tissue disorders.
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- - The rise of metabolic syndrome, especially in older adults, poses serious health issues, with hyperuricemia (high uric acid) being linked to both gout and age-related macular degeneration (AMD), a major eye disease affecting the elderly.
- - Inflammation plays a key role in the development of AMD, as recent research highlights the impact of uric acid's dual nature—acting as an antioxidant in the bloodstream and a pro-oxidant within cells.
- - There’s a growing indication that high serum uric acid levels may contribute to retinal diseases like AMD, suggesting the need for more research to explore the molecular connections and emphasizing the importance of interdisciplinary collaboration to fully understand these relationships.
Klotho is known for its age-suppressing function and has been implicated in sarcopenia pathology. It has recently been proposed that the adenosine A2B receptor plays a crucial role in skeletal muscle energy expenditure. However, the association between Klotho and A2B remains elusive.
View Article and Find Full Text PDFPurpose: Metabolic disorders have been implicated in ocular diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR). Recently, hyperuricemia (HUA) has been proposed as another risk factor for AMD, although no cause-and-effect experimental data have been published. In this study, we investigated whether HUA would initiate AMD or related retinal damages in hyperuricemic mice.
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