Unraveling cardiolipin-induced conformational change of cytochrome c through H/D exchange mass spectrometry and quartz crystal microbalance.

Cardiolipin (CL), a crucial component in inner mitochondrial membranes, interacts with cytochrome c (cyt c) to form a peroxidase complex for the catalysis of CL oxidation. Such interaction is pivotal to the mitochondrial regulation of apoptosis and is affected by the redox state of cyt c. In the present study, the redox-dependent interaction of cyt c with CL was investigated through amide hydrogen/deuterium exchange coupled with mass spectrometry (HDXMS) and quartz crystal microbalance with dissipation monitoring (QCM-D).

Design Reliable Bus Structure Distributed Fiber Bragg Grating Sensor Network Using Gated Recurrent Unit Network.

The focus of this paper was designing and demonstrating bus structure FBG sensor networks using intensity wavelength division multiplexing (IWDM) techniques and a gated recurrent unit (GRU) algorithm to increase the capability of multiplexing and the ability to detect Bragg wavelengths with greater accuracy. Several Fiber Bragg grating (FBG) sensors are coupled with power ratios of 90:10 and 80:10, respectively in the suggested experimental setup. We used the latest IWDM multiplexing technique for the proposed scheme, as the IWDM system increases the number of sensors and allows us to alleviate the limited operational region drawback of conventional wavelength division multiplexing (WDM).

Elucidation of tRNA-cytochrome c interactions through hydrogen/deuterium exchange mass spectrometry.

Cytochrome c (cyt c) is a mitochondrial protein responsible for transferring electrons between electron transport chain complexes III and IV. The release of cyt c from the mitochondria has been considered as a commitment step in intrinsic apoptosis. Transfer RNA (tRNA) has recently been found to interact with the released cyt c to prevent the formation of the apoptosome complex, thus preventing cell apoptosis.

Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.

Cdc42 regulates pathways related to cell division. Dysregulation of Cdc42 can lead to cancer, cardiovascular diseases and neurodegenerative diseases. GTP induced activation mechanism plays an important role in the activity and biological functions of Cdc42.

Neural correlates of successful response inhibition in unmedicated patients with late-life depression.

Objective: Accumulating evidence implicates a strong association between abnormal frontostriatal-limbic brain circuits, executive dysfunction, and late-life depression (LLD). The stop signal task (SST) was designed by Rubia et al. for use with functional magnetic resonance imaging (fMRI) to identify the neural correlates of motor response inhibition, a well-characterized executive function.

Distribution of allergens in children with different atopic disorders in central Taiwan.

Allergic disorders, including asthma, allergic rhinitis, and eczema, are the most common chronic childhood diseases. Exposure to house dust mites (HDMs) can exacerbate allergic disorders in sensitized individuals. The data for sensitization to HDMs and other frequent allergens amongst atopic children in Taiwan is limited.