Publications by authors named "Hung H Dang"
Article Synopsis
- C-di-AMP is crucial for bacterial functions like stress response, maintaining cell wall integrity, and virulence, but its precise molecular mechanisms are not fully understood.
- A mutant strain lacking c-di-AMP phosphodiesterases (ΔPDE) shows reduced virulence in a mouse infection model and is impaired in expressing virulence genes that are typically activated by reduced glutathione (GSH).
- The ΔPDE strain also has lower GSH levels and is less able to absorb GSH, suggesting that the buildup of c-di-AMP hinders GSH metabolism, which might explain its decreased virulence despite some restoration of gene expression through a modified PrfA protein.
Background: Despite extensive research on Guillain-Barré syndrome (GBS) in adults and children, there is a lack of comparison regarding short-term outcomes in various age groups. Our study aims to elucidate the differences in clinical features and short-term outcomes in Vietnam.
Methods: After retrospective data collection, we compared clinical features in patients with GBS aged ≤16 years at Children's Hospital 2 and aged >16 years at University Medical Center Ho Chi Minh City from 2017 to 2021.
NMR spectroscopy is a powerful tool to investigate molecular structure and dynamics. The poor sensitivity of this technique, however, limits its ability to tackle questions requiring dilute samples. Low-concentration photochemically induced dynamic nuclear polarization (LC-photo-CIDNP) is an optically enhanced NMR technology capable of addressing the above challenge by increasing the detection limit of aromatic amino acids in solution up to 1000-fold, either in isolation or within proteins.
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