Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals.

Importance: One approach to understanding the genetic complexity of schizophrenia is to study associated behavioral and biological phenotypes that may be more directly linked to genetic variation.

Objective: To identify single-nucleotide polymorphisms associated with general cognitive ability (g) in people with schizophrenia and control individuals.

Design, Setting, And Participants: Genomewide association study, followed by analyses in unaffected siblings and independent schizophrenia samples, functional magnetic resonance imaging studies of brain physiology in vivo, and RNA sequencing in postmortem brain samples.

Modeling of multisensory convergence with a network of spiking neurons: a reverse engineering approach.

Multisensory processing in the brain underlies a wide variety of perceptual phenomena, but little is known about the underlying mechanisms of how multisensory neurons are formed. This lack of knowledge is due to the difficulty for biological experiments to manipulate and test the parameters of multisensory convergence, the first and definitive step in the multisensory process. Therefore, by using a computational model of multisensory convergence, this study seeks to provide insight into the mechanisms of multisensory convergence.