MANAGERIAL COMPETENCE DEVELOPMENT IN THE CONTEXT OF PHILOSOPHY OF EDUCATION.

Objective: The aim: To analyze the problem of university management in the cultural and philosophical aspects.

Patients And Methods: Materials and methods: The research was conducted in the form of a written questionnaire. Students were supposed to give a single answer to each question.

INTERDEPENDENCE OF THE MICROBIOCENOSE COMPOSITION OF BIOPELLICLE AND THE SEVERITY DEGREE OF CHANGES IN THE MUCOSA OF THE GUMS AFTER TEN WEEKS OF EXPERIMENTAL OPIOID EXPOSURE.

Objective: The aim: To study the relationship between the degree severity of changes in the tunica mucosa of the rats gums and the composition of the microbiota of tooth surface in the gingival margin under the ten-week action of the opioid.

Patients And Methods: Materials and methods: The study was performed on 34 male rats, weighing 160 - 255 g, aged 4.5 - 7 months.

HEALTH DYNAMICS OF THE MEDICAL UNIVERSITY STUDENTS DURING SPORTS ACTIVITIES.

Objective: The aim: Is to investigate the dynamics of the morphofunctional development and physical health of students who were engaged in strength sports while studying at university.

Patients And Methods: Materials and methods: The study involved 360 male students of different faculties between the ages of 17 and 20. Two groups of students were formed: experimental and control groups.

Time to breast cancer relapse predicted by primary tumour characteristics, not lymph node involvement.

Introduction: The risk of breast cancer recurrence has been linked to tumour size, grade, oestrogen (ER) receptor status, and degree of lymph node (LN) involvement. However, the role of these variables in predicting time to relapse is not well defined. This study was designed to identify patient and primary tumour characteristics that predict risk periods for breast cancer recurrence within our institution, to enable more tailored surveillance strategies.

[Exocytotic steps in cell-free system after cholesterol deprivation in synaptosomal plasma membranes and synaptic vesicles].

Using a cell-free system we investigated a specific role of cholesterol in exocytotic processes. To modulate the cholesterol content in membrane methyl-beta-cyclodextrin was used as a cholesterol binding agent. The experimental conditions for cholesterol depletion from synaptosomal membrane structures were determined and depended on methyl-beta-cyclodextrin concentration, time and mediums temperature.

Arteriovenous malformations in Cowden syndrome.

Cowden syndrome (OMIM No 158350) is a pleomorphic, autosomal dominant syndrome characterised by hamartomas in tissues derived from the endoderm, mesoderm, and ectoderm. It is caused by germline mutations in the PTEN gene and is allelic to the Bannayan-Riley-Ruvalcaba and Lhermitte-Duclos syndromes. The three syndromes are defined on clinical grounds but there is overlap in their definitions.

[Modulating effect of anticonvulsive agents on Ca2+ dependent membrane fusion in cell-free model of neurosecretion].

The effect of antiepileptic drug ethosuximide and sodium valproat on fusion of synaptic vesicles with synaptosomal plasma membranes was studied in cell-free system. It was shown that ethosuximide and sodium valproat increases the rate of Ca(2+)-dependent fusion reaction in vitro. We have found that convulsant drugs pentylenetetrazol and picrotoxin did not fuse membrane components of the model system.

Successful treatment of radiation induced breast ulcer with hyperbaric oxygen.

The purpose of this report was to investigate the efficacy of hyperbaric oxygen treatment in the management of a persisting radiation induced ulcer following standard breast irradiation. A 57-year-old Caucasian patient was referred following partial mastectomy and axillary node clearance for a T2N0 grade 3 infiltrating ductal carcinoma of the left breast. She received 45 Gy in 25 fractions at 1.

Locally advanced breast cancer: is surgery warranted following chemotherapy?

Various methods of management of locally advanced breast cancer have been proposed, including combinations of chemotherapy, surgery, radiotherapy, immunotherapy and hormone manipulation. This retrospective study evaluated the effectiveness of chemotherapy in the management of locally advanced breast cancer in pre- and perimenopausal women by examining the pathology of the mastectomy specimens. Sixteen women who on initial clinical examination had breast cancers measuring 5 cm or greater underwent chemotherapy prior to surgery.

[High-sulfur protein subunits in keratins].

The quaternary structure of keratins contains a definite amount (to 40%) of protein-subunits with higher content of sulphur composing cystine, cysteine and other derivatives of these amino acids. These proteins are characterized by low molecular weight (to 30 kDa), significant heterogeneity and disordered, most probably, globular ternary structure in a free state. Being a constituent of the amorphous part of keratin (the so-called "matrix") and forming numerous intra- and intermolecular disulphide links, they stabilize the quaternary structure and promote resistance of keratins in solution and action of proteolytic enzymes.

Benign breast disease. A practical guide.

A concise working guide to the syndrome of benign breast disorder is given for the busy general practitioner. An outline of the symptoms, current thoughts on pathophysiology and recommendations for treatment are discussed.

Mammographic hook wire localization--a step by step guide.

A practical approach to hook wire localization of impalpable mammographic lesions is described, together with hints and potential pitfalls. A standard set of five radiographic projections is outlined. This consists of: 1.

Elastosis and primary breast cancer.

One hundred sixty-five patients with primary operable breast cancer were followed for up to 60 months. Each patient had the amount of focal elastosis and the estrogen-receptor activity within the tumor determined, as well as the tumor size, axillary nodal palpability, and nodal involvement. The risks of recurrence and death were compared by constructing life tables and assessing differences in various subgroups.

Localization and excision of occult breast lesions.

Between 1976 and 1982, 190 non-palpable mammographic abnormalities considered to be suspicious of malignancy were excised using a needle localization technique. The indications for biopsy, technique for localization, method for confirmation of excision and histopathological preparation are presented. The histopathological diagnosis of these lesions were 150 benign and 40 malignant.

Breast localization biopsy.

Nineteen localization biopsies were performed on eighteen women, where routine mammography revealed impalpable abnormalities. These abnormalities are described and the results of biopsy given. Six carcinomas were detected, all of which were shown to have no evidence of metastatic disease.

Oestrogen receptors and primary breast cancer.

Oestrogen receptor activity has been determined in the primary tumours from 243 patients with breast cancer and the subsequent clinical course of the disease has been followed for one to five years. Patients with oestrogen receptor-negative tumours had significantly shorter disease free intervals and survival times than those with receptor-positive tumours. Patients with large tumours, or with palpable axillary lymph nodes, or with histopathologically proven involvement of axillary lymph nodes also had a poorer prognosis than those with small tumours, impalpable nodes or histopathologically noninvaded nodes.

Milk protein concentrations in the mammary secretions of non-lactating women.

Milk protein concentrations were determined either by double antibody radioimmunoassay (IgA and IgG) or single radial immunodiffusion (lactoferrin) in the mammary secretions of seven healthy non-lactating subjects and eight patients with breast disease. IgA and IgG were detected in all samples of breast secretion (whether from normal or diseased breasts) and the concentrations observed were very similar to those in post-partum colostrum and milk. However, because the volume of secretion obtained was very small compared with colostrum and milk, total IgA synthesis by the non-lactating breast is very much less than in the lactating breast.

Factors affecting dehydroepiandrosterone sulphate levels in human breast secretions.

Human breast secretions as collected by nipple aspiration have been analysed for dehydroepiandrosterone sulphate by radioimmunoassay. All secretions collected from non-lactating normal women contained remarkably high levels of dehydroepiandrosterone sulphate as compared with plasma taken at the same time. Although there was a large range of concentrations, levels were of a similar magnitude in different ducts from the same breast and in different breasts from the same individual.

Preoperative assessment and staging of breast cancer: preliminary communication.

A prospective study has been carried out in 172 women to determine the sensitivity of methods to detect occult metastatic disease in the skeleton and liver. With the exception of bone scintiscans, the results of these tests bore little relationship to recurrence rates. On the other hand, knowledge of the histopathology of the lower axillary (pectoral) lymph nodes is of value in this respect.