The efficacy of 2-formyl benzoic acid in reactivating diazinon inhibited murine cholinesterase.

Oximes, as classical acetylcholinesterase (AChE) reactivators, have some pharmacokinetics/pharmacodynamics disadvantages. During the synthesis of non-oxime compounds, we encountered the compound 2-formylbenzoic acid (2-FBA) with promising in vitro and in vivo cholinesterase (ChE) reactivating properties in the acute exposure to diazinon (DZN). For in vitro experiments, the healthy mice serum and brain homogenate were freshly prepared and exposed to DZN (160 µg/mL).

Efficacy Of Hydrogen Peroxide Fumigation In Improving Disinfection Of Hospital Rooms And Reducing The Number Of Microorganisms.

Background: The hospital acquired infections are very common in any health care setting due to certain bacteria, viruses and fungi. In order to find out a solution to this problem, this preliminary study was designed to find out the efficiency of hydrogen peroxide fumigation in reducing the number of microorganisms and improving the disinfection of hospital rooms. It was a prospective cross over study, conducted in Arar Central Hospital, North region, Arar, Kingdom of Saudi Arabia, for the period of one year, from March 2015 to February 2016.