Publications by authors named "Hulya A Aydin"
Article Synopsis
- Red ginseng (Rg) has been traditionally used for medicinal purposes and this study investigates its effects on wound healing in diabetic rats through various application methods (local, systemic, and combined).
- In the experiment, 60 rats were divided into four groups, and a wound was treated with Rg extracts over 14 days, showing improved wound contraction in all treated groups compared to the control.
- The results indicated that while all Rg applications enhanced healing, the combined treatment showed the best outcomes with elevated VEGF levels and a more favorable immune response ratio.
Purpose: Our purpose was to comparatively investigate the expressions of nidogen-1 (NID1) and legumain (LGMN) in patients with endometrial cancer, endometrial intraepithelial neoplasia, and proliferative endometrium.
Methods: A cross-sectional, single-center study was performed by the obstetrics and gynecology and pathology departments of our institution. The relationships between descriptive data, clinicopathologic information, and immunohistochemical expressions of NID1 and LGMN were investigated.
Objective: Extrauterine tumor spread is one of the essential determinants of disease outcome in endometrial cancer. However; more than 30% of patients still undergo incomplete surgery at the initial attempt. Strategies regarding the management of patients with incompletely staged early-stage disease or patients with undebulked advanced-stage disease remain controversial.
View Article and Find Full Text PDFIn the current study, we primarily aimed to investigate stanniocalcin-2 (STC) protein expression pattern in hysterectomy specimens from patients with endometrioid type endometrial cancer (EC) using immunohistochemistry. Secondly, in order to clarify its prognostic impact, we examined relationships of the expression levels of STC with clinicopathologic features and outcome of patients. Histopathology slides of 49 patients were stained with the monoclonal mouse antibody targeting STC protein.
View Article and Find Full Text PDFObjective: ROS1 is an orphan receptor protein tyrosine kinase which is supposed to undergo genetic rearrangement in carcinogenesis. In the current study, we aimed to investigate the frequency and clinicopathologic features associated with ROS1 gene fusion and ROS1 protein expression in patients with ovarian serous carcinoma or serous borderline tumors.
Materials And Methods: Tissue samples of 102 patients with high or low grade serous carcinoma and borderline serous tumors were selected randomly from the archives of Department of Gyneco-pathology, and analyzed for ROS1 gene expression.
Purpose: Despite the common occurrence of adenomyosis in endometrial cancer (EC), there is a paucity and conflict in the literature regarding its impact on outcomes of patients. We sought to compare outcomes of patients with endometrioid type EC with or without adenomyosis.
Methods: A total of 314 patients were included in the analysis.
Article Synopsis
- This study examined the link between serum ghrelin levels and large-for-gestational-age (LGA) fetuses in women with gestational diabetes mellitus (GDM).
- Researchers compared four groups of pregnant women based on their glucose tolerance and fetal size: GDM with LGA, GDM with appropriate-for-gestational-age (AGA), normal glucose tolerance (NGT) with LGA, and NGT with AGA.
- Results showed higher ghrelin levels in the GDM groups, with abdominal circumference being the main predictor of LGA fetuses in the final analysis.