The importance of drug toxicity assessment lies in ensuring the safety and efficacy of the pharmaceutical compounds. Predicting toxicity is crucial in drug development and risk assessment. This study compares the performance of GPT-4 and GPT-4o with traditional deep-learning and machine-learning models, WeaveGNN, MorganFP-MLP, SVC, and KNN, in predicting molecular toxicity, focusing on bone, neuro, and reproductive toxicity.
View Article and Find Full Text PDFTransient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel critical for maintaining intracellular Ca homeostasis and is essential in regulating immune responses, metabolic processes, and signal transduction. Recent studies have shown that TRPV4 activation enhances influenza A virus infection, promoting viral replication and transmission. However, there has been limited exploration of antiviral drugs targeting the TRPV4 channel.
View Article and Find Full Text PDFSweetness in food delivers a delightful sensory experience, underscoring the crucial role of sweeteners in the food industry. However, the widespread use of sweeteners has sparked health concerns. This underscores the importance of developing and screening natural, health-conscious sweeteners.
View Article and Find Full Text PDFVitamin B is a group of biologically active cobalamin compounds. In this study, we investigated the inhibitory effects of methylcobalamin (MeCbl) and hydroxocobalamin acetate (OHCbl Acetate) on protein tyrosine phosphatase 1B (PTP1B). MeCbl and OHCbl Acetate exhibited an IC of approximately 58.
View Article and Find Full Text PDFGout, a painful condition marked by elevated uric acid levels often linked to the diet's high purine and alcohol content, finds a potential treatment target in xanthine oxidase (XO), a crucial enzyme for uric acid production. This study explores the therapeutic properties of alkaloids extracted from sunflower (Helianthus annuus L.) receptacles against gout.
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