Publications by authors named "Huizi Cui"

The importance of drug toxicity assessment lies in ensuring the safety and efficacy of the pharmaceutical compounds. Predicting toxicity is crucial in drug development and risk assessment. This study compares the performance of GPT-4 and GPT-4o with traditional deep-learning and machine-learning models, WeaveGNN, MorganFP-MLP, SVC, and KNN, in predicting molecular toxicity, focusing on bone, neuro, and reproductive toxicity.

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Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel critical for maintaining intracellular Ca homeostasis and is essential in regulating immune responses, metabolic processes, and signal transduction. Recent studies have shown that TRPV4 activation enhances influenza A virus infection, promoting viral replication and transmission. However, there has been limited exploration of antiviral drugs targeting the TRPV4 channel.

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Article Synopsis
  • * GPT-4 demonstrated significant accuracy in predicting binding affinities, achieving 87.31% for RAF and outperforming traditional methods, indicating its potential for more reliable drug discovery processes.
  • * Additional testing with other kinases confirmed GPT-4's generalizability, achieving a maximum accuracy of 83.78%, with implications for advancements in biological research and therapeutic development.
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  • Reproductive toxicity can greatly affect fertility and the health of offspring, making it vital to identify these risks in pharmaceutical compounds.
  • The study examined different reproductive toxic molecules, categorizing them into three types and employing advanced analysis methods to uncover complex toxicity mechanisms.
  • Utilizing machine learning techniques, including Support Vector Machines and deep learning models, the research achieved high accuracy in predicting reproductive toxicity, emphasizing the effectiveness of computational methods for assessing pharmaceutical safety.
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Sweetness in food delivers a delightful sensory experience, underscoring the crucial role of sweeteners in the food industry. However, the widespread use of sweeteners has sparked health concerns. This underscores the importance of developing and screening natural, health-conscious sweeteners.

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Vitamin B is a group of biologically active cobalamin compounds. In this study, we investigated the inhibitory effects of methylcobalamin (MeCbl) and hydroxocobalamin acetate (OHCbl Acetate) on protein tyrosine phosphatase 1B (PTP1B). MeCbl and OHCbl Acetate exhibited an IC of approximately 58.

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Article Synopsis
  • * Inflammation plays a significant role in worsening insulin resistance, creating a cycle that can be targeted with anti-inflammatory treatments for managing T2DM.
  • * The study explored the anti-diabetic effects of Baikal skullcap, identifying six flavonoids, including baicalein, as effective in reducing diabetes by inhibiting the PTP1B enzyme and providing anti-inflammatory benefits, potentially paving the way for new herbal-based therapies.
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Gout, a painful condition marked by elevated uric acid levels often linked to the diet's high purine and alcohol content, finds a potential treatment target in xanthine oxidase (XO), a crucial enzyme for uric acid production. This study explores the therapeutic properties of alkaloids extracted from sunflower (Helianthus annuus L.) receptacles against gout.

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