The Bioactive Compounds of and Their Potential Mechanism of Action in Treating Osteoporosis: A Network Pharmacology and Experimental Validation Study.

Osteoporosis is a global health challenge characterized by bone loss and microstructure deterioration, which urgently requires the development of safer and more effective treatments due to the significant adverse effects and limitations of existing drugs for long-term treatment. Traditional Chinese medicine, like , offers fewer side effects and has been used to treat osteoporosis, yet its active compounds and pharmacological mechanisms remain unclear. In this study, 65 potential active compounds, 258 potential target proteins, and 488 pathways of were identified through network pharmacology analysis.

Doing more with less: How to design a good subgroup governance model for the air pollution transport network in "2+26" cities of China?

Air pollution shares the attributes of significant spatial spillover effects and environmental public goods, leading to the territorial governance model that easily falls into a state of failure. Despite a growing number of studies on the local spatial spillover effect of air pollution, scant evidence currently exists on its global spatial association effect and a good subgroup governance model. Based on a panel data set of the daily prefecture-level city data on air quality measured by the air quality index (AQI) in "2 + 26" cities of China in 2015 and 2018, this study first builds an air pollution transport network (APTN), i.

Spatiotemporal heterogeneity and influencing factors on urbanization and eco-environment coupling mechanism in China.

High-quality urbanization is the core for realizing human well-beings, for which reason investigating how the relationship evolves between urbanization and eco-environment is of crucial importance. Differing from the rationale of revealing spatial spillover effects using traditional tests, we consider spatial network characteristics to enrich the notion of local coupling and telecoupling from a relational perspective. First, we adopt coupling coordination degree model (CCDM) and decoupling model (DM) to calculate the urbanization and eco-environment coupling coordination degree (UECCD) and the decoupling index (DI) in 30 provinces and municipalities of China from 2008 to 2017.

Quantitative method for analysis of tobacco-specific N-nitrosamines in mainstream cigarette smoke by using heart-cutting two-dimensional liquid chromatography with tandem mass spectrometry.

A heart-cutting two dimensional liquid chromatography coupled with tandem mass spectrometry method was developed for the analysis of tobacco-specific N-nitrosamines (TSNAs) at low concentration level in Virginia-type cigarette smoke. A strong cation exchange column was utilized for the first dimensional separation, which effectively removed acidic and neutral components in the smoke, followed by a reversed phase liquid chromatography coupled with tandem mass spectrometric analysis. To capture components of the TSNAs in the effluent on the trapping column, a compensating pump was applied for online dilution and pH adjustment during the period of the TSNAs fraction transferring and enrichment.