Publications by authors named "Huize Xia"
Adv Sci (Weinh)
October 2024
Article Synopsis
- Breast cancer patients often face treatment resistance due to chemoresistant breast cancer stem cells (BCSCs), which contribute to cancer recurrence and spread.
- Researchers developed an mRNA-based BCSC signature using machine learning to assess cancer stemness in patient samples and discovered that polyamine anabolism, influenced by the HIF-1 transcription factor, plays a crucial role in enhancing BCSC levels following chemotherapy.
- A natural compound, britannin, was found to inhibit HIF-1 activity, leading to reduced polyamine production and BCSC enrichment, suggesting a promising new approach for improving breast cancer treatment outcomes.
