Publications by authors named "Huiyu Wu"

Article Synopsis
  • PM2.5 is a type of air pollution that can cause serious respiratory inflammation and related diseases.
  • This study explores whether mycelia, known for their medicinal properties, can help reduce PM2.5-induced lung inflammation and inflammation-related molecules.
  • Findings indicate that mycelia effectively lower nitric oxide production and the activation of inflammatory pathways in macrophages, suggesting their potential as a treatment for respiratory issues related to PM2.5 exposure.
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  • Cigarette smoking is a major cause of death globally and has been shown to increase the infectivity of Streptococcus pneumoniae, a harmful bacteria that often affects the respiratory system.
  • This study utilized cigarette smoke extract (CSE) to examine how it impacts the innate immune response, specifically in mouse macrophage models.
  • Findings revealed that CSE exposure reduces the production of key immune signaling molecules and disrupts macrophage functions, ultimately weakening the body's defense against pneumococcal infections.
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Background: Cytolethal distending toxin (CDT) belongs to the genotoxin family and is closely related to Campylobacter jejuni-associated gastroenteritis. We recently reported that CDT triggers the danger-associated molecular pattern (DAMP) signaling to exert deleterious effects on host cells. However, how CDT traffics in cells and the mechanism of CDT intoxication remain to be elucidated.

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Inflammation plays a key role in pathogenesis and rupture of aneurysms. Non-invasively and dynamically monitoring aneurysm inflammation is critical. This study evaluated myeloperoxidase (MPO) as an imaging biomarker and therapeutic target for aneurysm inflammation using an elastase-induced rabbit model treated with or without 4-aminobenzoic acid hydrazide (ABAH), an irreversible inhibitor of MPO.

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Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic effects remain unclear. Lactic acid bacteria, specifically spp.

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Objectives: To explore the molecular characteristics of rpoB, encoding β-subunit of DNA-directed RNA polymerase, and unravel the link to rifabutin-resistance in patients with refractory Helicobacter pylori infection.

Methods: From January 2018-March 2021, a total of 1590 patients were screened for eligibility to participate in the study. Patients with refractory H.

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is an emerging spore-forming anaerobe that is often observed in -associated inflammatory bowel disease (IBD) exacerbations. Unlike , neither produces toxins nor possesses toxin-encoding genetic loci, but is commonly found in both intestinal and extra-intestinal infections. Membrane lipid rafts are composed of dynamic assemblies of cholesterol and sphingolipids, allowing bacteria to gain access to cells.

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Background/purpose: The simulated color of restorations plays an important role in improving patient satisfaction. The aim of this study was to test a new intelligent colorimetric solution using the Advanced Reflectionless Technology (ART) monitor and compare them using commercially available shade systems.

Materials And Methods: Six participants' right maxillary central incisors were tested with three devices, including the AUO Display Plus (Group A), a Canon single-lens reflex camera with eLAB's polar eyes filter (Group E), and the VITA Easyshade V (Group V).

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  • This study aimed to develop a new toothpaste with dicalcium phosphate anhydrous (DCPA) and evaluate its effects on tooth health compared to two commercial brands.
  • Results showed that the new toothpaste had superior microhardness and better sealing of dentinal tubules over time, indicating increased effectiveness.
  • Overall, the innovative toothpaste outperformed the commercial options in enhancing tooth properties and maintaining oral health.
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Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects.

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Background: Primary Ewing's sarcoma of sphenoid sinus, observed in children and adolescents, is an extremely rare malignancy. Such rarity makes the imaging features and treatment strategies for Ewing's sarcoma of sphenoid sinus unclear. This study aimed to offer guidance for treating this very disease by describing a patient with a rare primary Ewing's sarcoma of sphenoid sinus and reviewing the available data in the literature.

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  • Amoxicillin resistance in Helicobacter pylori is linked to specific mutations in the penicillin-binding protein-1A (PBP-1A), but the exact mutations responsible are not fully understood.
  • The study investigated patients with ongoing H. pylori infections after multiple treatment attempts by analyzing gastric biopsy samples to identify resistant strains and their genetic mutations.
  • Results showed that 17 out of 39 cultured H. pylori isolates were amoxicillin-resistant, with multiple PBP-1A mutations present, suggesting a strain-specific mechanism for resistance, highlighting a need for better diagnostic tools in managing such infections.*
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Triple negative breast cancer (TNBC) has negative expression of ER, PR and HER-2. TNBC shows high histological grade and positive rate of lymph node metastasis, easy recurrence and distant metastasis. Molecular typing based on metabolic genes can reflect deeper characteristics of breast cancer and provide support for prognostic evaluation and individualized treatment.

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infection is closely associated with various gastrointestinal diseases and poses a serious threat to human health owing to its increasing antimicrobial resistance. possesses two major virulence factors, vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), which are involved in its pathogenesis. Probiotics have recently been used to eradicate infection and reduce the adverse effects of antibiotic-based therapies.

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Mounting evidence indicates that the gut microbiota is linked to several physiological processes and disease development in mammals; however, the underlying mechanisms remained unexplored mostly due to the complexity of the mammalian gut microbiome. The fruit fly, , is a valuable animal model for studying host-gut microbiota interactions in translational aspects. The availability of powerful genetic tools and resources in allowed the scientists to unravel the mechanisms by which the gut microbes affect fitness, health, and behavior of their hosts.

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infection is associated with several gastrointestinal diseases, including gastritis, peptic ulcers, and gastric cancer. Infection of cells with is dependent on lipid rafts, which are cholesterol-rich microdomains located in the cell membrane. cholesterol-α-glucosyltransferase (CGT) catalyzes the conversion of membrane cholesterol to cholesteryl glucosides, which can be incorporated into the bacterial cell wall, facilitating evasion from immune defense and colonization in the host.

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infection is associated with several gastrointestinal diseases, including gastritis, peptic ulcer, and gastrointestinal adenocarcinoma. Two major cytotoxins, vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), interact closely with lipid rafts, contributing to -associated disease progression. The cytolethal distending toxin consists of three subunits: CdtA, CdtB, and CdtC.

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Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA). It has been found to be abundantly expressed in cancer stem cells (CSCs) that often exhibit a radioresistant phenotype.

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Objective: To study the expression of IL13RA2 in gliomas and to analyze its correlation with clinicopathological/molecular features, immune cell infiltration and prognostic significance.

Methods: mRNA expression data for IL13RA2 were downloaded and analyzed from two open access datasets (TCGA & CGGA). IL13RA2 protein expression was examined by immunohistochemistry.

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, an obligate anaerobic gram-positive bacillus, generates spores and is commonly found colonizing the human gut. Patients with infection (CDI) often exhibit clinical manifestations of pseudomembranous colitis or antibiotic-associated diarrhea. Surface layer proteins (SLPs) are the most abundant proteins in the cell wall, suggesting that they might involve in immune recognition.

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Background: Pneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM) is known to significantly contribute to respiratory diseases.

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Cold atmospheric plasma jet (CAPJ) or non-thermal plasma jet has been employed in various biomedical applications based on their functions in bactericidal activity and wound healing. However, the effect of CAPJ generated by a particular composition of gases on wound closure and the underlying mechanisms that regulate wound healing signals remain elusive. In the present study, we investigated the impact of helium (He)- or a gas mixture of He and argon (He/Ar)-generated CAPJ on cell proliferation, which is a pivotal step during the wound healing process.

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The latest WHO classification of CNS tumors using the integrated phenotypic and molecular parameters (IDH, ATRX, 1p19q, TERT etc.) have reestablished the CNS tumors classification in addition to traditional histology. The establishment of glioma molecular typing can more accurately predict prognosis, better guide individualized treatment to improve survival.

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Article Synopsis
  • The study investigates the role of interleukin-33 (IL-33) in the immune response to a specific bacterial infection that affects human gastric epithelial cells and can lead to gastrointestinal disorders.
  • It highlights that IL-33 interacts with its receptor ST-2, triggering inflammatory signaling pathways, and shows that this interaction is enhanced during infection.
  • The research found increased levels of IL-33 and ST-2 in infected cells, with lipid rafts playing a crucial role in this process, which ultimately contributes to inflammation and immune cell infiltration in gastric tissues.
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