Efficiency and safety of automated label cleaning on multimodal retinal images.

Label noise is a common and important issue that would affect the model's performance in artificial intelligence. This study assessed the effectiveness and potential risks of automated label cleaning using an open-source framework, Cleanlab, in multi-category datasets of fundus photography and optical coherence tomography, with intentionally introduced label noise ranging from 0 to 70%. After six cycles of automatic cleaning, significant improvements are achieved in label accuracies (3.

Electrochemical-coupled sulfur-driven autotrophic denitrification for nitrogen removal from raw landfill leachate: Evaluation of performance and mechanisms.

The cost-effective and environment-friendly sulfur-driven autotrophic denitrification (SdAD) process has drawn significant attention for advanced nitrogen removal from low carbon-to-nitrogen (C/N) ratio wastewater in recent years. However, achieving efficient nitrogen removal and maintaining system stability of SdAD process in treating low C/N landfill leachate treatment have been a major challenge. In this study, a novel electrochemical-coupled sulfur-driven autotrophic denitrification (ESdAD) system was developed and compared with SdAD system through a long-term continuous study.

Factors affecting cognitive frailty improvement and progression in Taiwanese older adults.

Background: Knowledge of predictors of cognitive frailty (CF) trajectories is required to develop preventive strategies to delay or reverse the progression from CF to dementia and other adverse outcomes. This 2-year prospective study aimed to investigate factors affecting the progression and improvement of CF in older Taiwanese adults.

Methods: In total, 832 community-dwelling people aged ≥ 65 years were eligible.

Astragalus polysaccharide promotes autophagy and alleviates diabetic nephropathy by targeting the lncRNA Gm41268/PRLR pathway.

Background: Astragalus polysaccharide (APS) is a major bioactive component of the Chinese herb astragalus, with well-established protective effects on the kidney. However, the effect of APS on diabetic nephropathy (DN) is unclear.

Methods: Long non-coding RNA (lncRNA) expression profiles in kidney samples from control, db/db, and APS-treated db/db mice were evaluated using RNA high-throughput sequencing techniques.

Highly efficient decomplexation of chelated nickel and copper effluent through CuO-CeO-CoO nanocatalyst loaded on ceramic membrane.

A novel CuO-CeO-CoO nanocatalyst loaded on AlO ceramic composite membrane (CCM-S) was synthesized through spraying-calcination method, which can be beneficial to the engineering application of scattered granular catalyst. BET and FESEM-EDX testing revealed that CCM-S possessed a porous character with high BET surface area of 22.4 m/g and flat modified surface with extremely fine particle aggregation.

Inhibition of ferroptosis ameliorates hypertensive nephropathy through p53/Nrf2/p21 pathway by Taohongsiwu decoction: Based on network pharmacology and experimental validation.

Ethnopharmacological Relevance: Hypertensive nephropathy (HN) is a complication of hypertension. Taohongsiwu decoction (THSWD) is used clinically but its application in the prevention and treatment of HN remains unelucidated.

Aim Of Study: This study aims to explore the potential targets and molecular mechanisms of THSWD in the treatment of HN.

Ocular Trauma During COVID-19 Pandemic: A Systematic Review and Meta-analysis.

Purpose: This study aimed to summarize the latest literature on the trends and incidence of ocular trauma during the COVID-19 pandemic.

Design: Systematic review and meta-analysis.

Methods: A systematic literature search was conducted to identify the relevant literature.

Determinants of the health care service choices of long-term mechanical ventilation patients: Applying andersen's behavioral model.

Aims: The number of ventilator-dependent patients is rapidly increasing globally. As a result, long-term mechanical ventilation (LTMV) patients face the choice of receiving health care in respiratory care wards (RCWs) rather than at home. In this study, we applied Andersen's behavioral theoretical model (ABM) to investigate the determinants of the health care service decisions of patients receiving LTMV.

Micro and nano bubbles promoted biofilm formation with strengthen of COD and TN removal synchronously in a blackened and odorous water.

Blackening and odorization of rivers (BOR) distributed widely in urban cities with high density of human beings. Amounts of pollution control methods have been developed for treatment of these contaminated rivers. Among them, artificial aeration is an effective method for BOR treatment.

Decomplexation removal of Ni(II)-citrate complexes through heterogeneous Fenton-like process using novel CuO-CeO-CoO composite nanocatalyst.

A novel CuO-CeO-CoO nanocatalyst was prepared for heterogeneous Fenton-like reaction to break the Ni-chelate into free Ni in electroless nickel plating wastewater, followed by separation of Ni in an insoluble form. The composite nanocatalysts prepared by co-precipitation method were characterized by XRD, TEM, and XPS, et al. Its catalytic activity as Fenton-like reagent was evaluated by the removal efficiency of Ni(II)-citrate after decomplexation and postprecipitation treatment.

Enhanced photoelectrocatalytic degradation of bisphenol A and simultaneous production of hydrogen peroxide in saline wastewater treatment.

The degradation of organic pollutants in saline wastewater has been a challenge for environmental remediation. In this study, a two-chamber cell was structured to simultaneously degrade organic contaminants (bisphenol A, BPA) from saline wastewater and produce hydrogen peroxide (HO). In the anode chamber, a new solar-light-driven system was devised using chloride ions (Cl‾) as a medium and WO photoanode as a radical initiator.

Application of a Q Method Study to Understanding Nurses' Perspective of Adopting Evidence-Based Nursing.

Purpose: This study applied the Q method to identify and describe the various types of nurse perceptions that are crucially associated with their engagement in evidence-based nursing (EBN).

Methods: The study participants were nurses at a medical center and a regional teaching hospital. A series of Q sorts was performed by nurses to subjectively rank the Q statements.

Nurse characteristics, leadership, safety climate, emotional labour and intention to stay for nurses: a structural equation modelling approach.

Aim: The aim of this study was to propose a theoretical model and apply it to examine the structural relationships among nurse characteristics, leadership characteristics, safety climate, emotional labour and intention to stay for hospital nurses.

Background: Global nursing shortages negatively affect the quality of care. The shortages can be reduced by retaining nurses.

Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model.

An initial step in amyloid-β (Aβ) production includes amyloid precursor protein (APP) cleavage via β-Site amyloid precursor protein cleaving enzyme 1 (BACE1). Increased levels of brain Aβ have been implicated in the pathogenesis of Alzheimer's disease (AD). Thus, β-secretase represents a primary target for inhibitor drug development in AD.

A U87-EGFRvIII cell-specific aptamer mediates small interfering RNA delivery.

U87-EGFRvIII is a U87 glioma cell line that overexpresses epidermal growth factor receptor variant III (EGFRvIII). In the present study, we investigated whether a DNA aptamer selected against U87-EGFRvIII using cell-based systematic evolution of ligands by exponential enrichment (cell-SELEX) could deliver c-Met small interfering RNA (siRNA) into U87-EGFRvIII cells and silence the targeted gene expression. The selected biotinylated aptamer (BA) was coupled to biotinylated c-Met siRNA by streptavidin to deliver siRNA into U87-EGFRvIII cells.

Cell-SELEX aptamer for highly specific radionuclide molecular imaging of glioblastoma in vivo.

Glioblastoma (GBM) is the most frequent and aggressive primary adult brain tumor with poor prognosis. Epidermal growth factor receptor variant III (EGFRvIII) is the most common and highly oncogenic EGFR mutant in GBM. With the aim to generate specific molecular probes able to target EGFRvIII with high affinity, we selected four DNA aptamers (U2, U8, U19 and U31) specifically bound to U87-EGFRvIII cells that over expressed EGFRvIII with Kd values in the nanomole range by a cell-based systematic evolution of ligands by exponential enrichment (cell-SELEX) process.

DNA aptamers that target human glioblastoma multiforme cells overexpressing epidermal growth factor receptor variant III in vitro.

Aim: Aptamers are oligonucleic acid or peptide molecules that bind to a specific target molecule in cells, thus may act as effective vehicles for drug or siRNA delivery. In this study we investigated the DNA aptamers that target human glioblastoma multiforme (GBM) cells overexpressing epidermal growth factor receptor variant III (EGFRvIII), which was linked to radiation and chemotherapeutic resistance of this most aggressive brain tumor.

Methods: A 73-mer ssDNA library containing molecules with 30 nt of random sequence flanked by two primer hybridization sites was chosen as the initial library.

[Cell-ELA-based determination of binding affinity of DNA aptamer against U87-EGFRvIII cell].

A15, a DNA aptamer with binding specificity for U87 glioma cells stably overexpressing the epidermal growth factor receptor variant III (U87-EGFRvIII), was generated by cell systematic evolution of ligands by exponential enrichment (cell-SELEX) using a random nucleotide library. Subsequently, we established a cell enzyme-linked assay (cell-ELA) to detect the affinity of A15 compared to an EGFR antibody. We used A15 as a detection probe and cultured U87-EGFRvIII cells as targets.