Publications by authors named "Huiyong Huo"
Background: Our previous study discovers that Jun N-terminal kinase pathway-associated phosphatase (JKAP) is dysregulated and negatively links with the disease severity in acute ischemic stroke (AIS) patients. This study intended to further evaluate the linkage of JKAP and interleukin (IL)-17A with anxiety, depression, and cognitive impairment in AIS patients.
Methods: Serum JKAP and IL-17A levels in 120 AIS patients at admission, 1st (D1), 3rd (D3), 7th (D7) day after admission, and from 20 controls, were detected by ELISA.
Article Synopsis
- The study examines the role of JKAP in T-cell responses and inflammation in acute ischemic stroke (AIS) patients, particularly focusing on T-helper 1 (Th1) and T-helper 17 (Th17) cell levels.
- In 155 AIS patients, findings showed lower JKAP levels, higher Th17 cells, and a negative correlation between JKAP and both Th1/Th17 cells and inflammatory markers.
- Results suggest that higher JKAP levels may be associated with milder disease severity and potential benefits in recurrence-free survival among AIS patients.