Publications by authors named "Huixu Lu"
Article Synopsis
- The liver's biotransformation process can change nanoparticles' surface chemistry, affecting their ability to function and target specific cells.
- The study found that switching the bond in nanoparticles from gold-sulfur (Au-S) to gold-selenium (Au-Se) improved their targeting efficiency to liver cells by 15-fold and altered their transport behaviors in the liver.
- By enhancing the targeting of nanoparticles to liver tumors and reducing dissociation of targeting ligands, this research provides new insights and strategies for designing nanomedicines that can effectively navigate liver biotransformation.
Article Synopsis
- Renal clearable nanoparticles can effectively eliminate from the body through the kidneys, preventing harmful accumulation, but their interactions with other organs like the liver are still not fully understood.
- This study focused on a specific type of nanoparticle (800CW-GS-Au) that, despite showing minimal liver accumulation, underwent modifications due to liver interactions, which could be detected in urine.
- The findings suggest a way to noninvasively measure liver glutathione levels through urine analysis, enhancing understanding of nanoparticle transport and paving the way for new diagnostic methods.
The mortality rate of pneumonia increases significantly with the prolongation of illness. In the pursuit of a tool to accurately diagnose pneumonia in its early stages, we designed and synthesized a two-photon near-infrared fluorescent probe (DCQN) to identify increased concentrations of the inflammation marker SO. The probe was found to specifically react with SO by undergoing a 1,4-addition reaction to generate near-infrared fluorescence with good sensitivity (6 s), a large Stokes shift (110 nm) and low detection limit (1.
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