Evaluating vonoprazan and tegoprazan for gastroesophageal reflux disease treatment in Chinese Healthcare: an EVIDEM framework analysis.

Background: In Chinese healthcare settings, drug selection decisions are predominantly influenced by the Pharmacy & Therapeutics Committee (PTC). This study evaluates two recently introduced potassium-competitive acid blockers, vonoprazan (VPZ) and tegoprazan (TPZ), utilizing the Evidence and Value: Impact on DEcisionMaking (EVIDEM) framework.

Methods: The study employed the 10th edition of EVIDEM, which includes a core model with five domains and 13 criteria.

Elastic Polyurethane as Stress-Redistribution-Adhesive-Layer (SRAL) for Directly Integrated High-Energy-Density Flexible Batteries.

The low mechanical reliability and integration failure are key challenges hindering the commercialization of geometrically flexible batteries. This work proposes that the failure of directly integrating flexible batteries using traditional rigid adhesives is primarily due to the mismatch between the generated stress at the adhesive/substrate interface, and the maximum allowable stress. Accordingly, a stress redistribution adhesive layer (SRAL) strategy is conceived by using elastic adhesive to redistribute the generated stress.

Nanorod-like Bimetallic Oxide for Enhancing the Performance of Supercapacitor Electrodes.

Supercapacitors are widely used in many fields owing to their advantages, such as high power, good cycle performance, and fast charging speed. Among the many metal-oxide cathode materials reported for supercapacitors, NiMoO is currently the most promising electrode material for high-specific-energy supercapacitors. We have employed a rational design approach to create a nanorod-like NiMoO structure, which serves as a conductive scaffold for supercapacitors; the straightforward layout has led to outstanding results, with nanorod-shaped NiMoO exhibiting a remarkable capacity of 424.

Elevated matrix metalloproteinase‑9 expression is associated with COVID‑19 severity: A meta‑analysis.

The present meta-analysis investigated the clinical value of serum matrix metalloproteinase (MMP)-9 levels in Coronavirus Disease 2019 (COVID-19) patients. Studies assessing the outcomes of patients with COVID-19 in correlation with the MMP-9 levels were retrieved from PubMed, Web of Science, EMBASE, Cochrane, WANFANG, and CNKI. A meta-analysis was performed to compare the serum MMP-9 levels between different patient groups: Severe vs.

CircPCNX Promotes PDGF-BB-Induced Proliferation and Migration of Human Aortic Vascular Smooth Muscle Cells Through Regulating miR-1278/DNMT1 Axis.

Background: Human aortic vascular smooth muscle cells (HA-VSMCs) play vital roles in the pathogenesis of vascular diseases. Circular RNAs (circRNAs) have been reported to regulate the biological functions of HA-VSMCs. In this study, the functions of circRNA pecanex homolog (circPCNX) in platelet-derived growth factor-BB (PDGF-BB)-induced HA-VSMCs were investigated.

Atomistic mechanism of phase transformation between topologically close-packed complex intermetallics.

Understanding how topologically close-packed phases (TCPs) transform between one another is one of the challenging puzzles in solid-state transformations. Here we use atomic-resolved tools to dissect the transition among TCPs, specifically the μ and P (or σ) phases in nickel-based superalloys. We discover that the P phase originates from intrinsic (110) faulted twin boundaries (FTB), which according to first-principles calculations is of extraordinarily low energy.

Enhancing the Electrochemical Properties of Ti-Doped LiMnO Spinel Cathode Materials Using a One-Step Hydrothermal Method.

In this study, LiMn Ti O cathode materials were synthesized by a simple one-step hydrothermal method, and the effects of Ti doping on the sample structure and electrochemical properties were examined. The results indicated that Ti doping did not affect the spinel structure of LiMnO, and no other hybrid phases were produced. Furthermore, appropriate doping with Ti improved the particle uniformity of the samples.

NbCT MXene as High-Performance Energy Storage Material with Na, K, and Liquid K-Na Alloy Anodes.

Two-dimensional MXenes perform well as hosts in batteries, which are promising for next-generation energy storage materials. With low price and high performance, sodium (Na) and potassium (K) own the potential to replace lithium in energy storage devices, but the larger radii and dendrite growth restrict their commercialization. Herein, we successfully synthesized an accordion-like NbCT MXene, whose crystal structure integrity and lamellar separation have been confirmed by characterization methods like high-resolution transmission electron microscopy (HR-TEM).

Gaseous -- Property Measurements for Titanium Tetrachloride from 873.0 to 1173.0 K and Low Pressure of 34.05 kPa.

For exploring the chemical reaction mechanism and the heat and the mass transfer of the TiCl-Mg system in the Kroll process, it is of fundamental and practical importance to determine the gaseous -- property for titanium tetrachloride at supercritical temperature and low pressure. The - data for the TiCl + (1 - ) Ar binary gas system are measured and presented in this study. Based on the Peng-Robinson (P-R) equation of state (EoS) of argon at temperatures from 873.

Preparation of Imitation Basalt Compound Based on Thermodynamic Calculation.

In this paper, imitation basalt compounds using red mud, fly ash or coal gangue as raw materials were designed and prepared with the help of thermodynamic calculations. Thermodynamic calculations were used to obtain the suitable chemical composition. Then, the imitation compounds were prepared and their phase/compositions were analyzed.

Characterization of NiSn intermetallic nanoparticles fabricated by thermal plasma process and catalytic properties for methanol decomposition.

The intermetallic compound NiSn has potential for application in hydrogen production as a catalyst. Herein, we synthesized NiSn nanoparticles through a thermal plasma process. We characterized the nanoparticles by synchrotron radiation X-ray diffraction and transmission electron microscopy analyses, and analyzed their catalytic properties for methanol decomposition in a temperature range of 513 to 793 K.

Coarsening Behavior of Particles in Fe-O-Al-Ca Melts.

The characteristics of particles greatly affect the microstructure and performance of metallic materials, especially their sizes. To provide insight into coarsening phenomena of particles in metallic melts, Fe-O-Al-Ca melt with calcium aluminate particles was selected as a model system. This study uses HT-CSLM, SEM detections and stereological analysis to probe the behavior of particles and their characteristics including size, number density, volume fraction, spreading of particle size, inter-surface distance and distribution of particles.

Nucleation and Ostwald Growth of Particles in Fe-O-Al-Ca Melt.

Tremendous focus has been put on the control of particle size distribution which effects the grain structure and mechanical properties of resulting metallic materials, and thus nucleation and growth of particles in solution should be clarified. This study uses classical nucleation theory and Ostwald ripening theory to probe the relationship between the compositions of Fe-O-Al-Ca melts and the behavior of particles under the condition of no external stirring. Our experimental data suggest that decreasing the initial Ca addition and Al addition is conductive to the increase of nucleation rate for calcium aluminate particles, which exhibits a same change trend with that predicted from classical nucleation theory.

An exploratory survey of money boys and HIV transmission risk in Jilin Province, PR China.

This report represents the first exploratory study of Chinese men who provide commercial sex services to other men ("money boys") in Jilin Province, People's Republic of China, through a convenience sample drawn from Changchun and Jilin City. A total of 86 active money boy participants (Changchun, n = 49; Jilin City, n = 37) were surveyed concerning background and demographics, basic HIV transmission knowledge, and sexual practices. The survey indicated that while Jilin Province money boy behavior matches other studies concerning propensity to high risk behavior and significant bridging potential, the Jilin money boys, unlike previous studies, exhibited a high level of basic HIV/AIDS transmission knowledge.