Meta-analysis of the effectiveness and safety of magnetic stimulation for chronic pelvic pain.

Objective: To systematically assess the effectiveness and safety of magnetic stimulation (MS) for treating chronic prostatitis (CP) and chronic pelvic pain syndrome (CPPS) through a meta-analysis.

Methods: A comprehensive search of databases including PubMed, The Cochrane Library, EMbase, VIP, Web of Science, WanFang, China Biology Medicine disc (CBMdisc), and China National Knowledge Internet (CNKI) databases was conducted to retrieve randomized controlled trials (RCTs) on MS interventions for CPPS from inception to the present. The search employed keywords such as "MS", "CPPS", and "prostatitis".

Analysis of the function, mechanism and clinical application prospect of TRPS1, a new marker for breast cancer.

It has been discovered that Trichorhinophalangeal Syndrome-1 (TRPS1), a novel member of the GATA transcription factor family, participates in both normal physiological processes and the development of numerous diseases. Recently, TRPS1 has been identified as a new biomarker to aid in cancer diagnosis and is very common in breast cancer (BC), especially in triple-negative breast cancer (TNBC). In this review, we discussed the structure and function of TRPS1 in various normal cells, focused on its role in tumorigenesis and tumor development, and summarize the research status of TRPS1 in the occurrence and development of BC.

Ibuprofen induces hepatic Cyp7a1 expression in mice via the intestinal FXR-FGF15 signaling.

Non-steroidal anti-inflammatory drugs (NSAIDs) may cause drug-induced liver injury (DILI). However, the molecular mechanisms underlying NSAIDs hepatotoxicity remain elusive. Dysregulations of bile acids (BAs) have been implicated in various DILI.

Suspected coexistence of perianal necrotizing sweet syndrome in chronic myelomonocytic leukemia: A case report.

Background: Chronic myelomonocytic leukemia (CMML) complicated with Sweet syndrome (SS) is a rare hematological neoplasm. However, cases of concomitant development of perianal necrotizing SS (NSS) have not been reported.

Case Summary: We report a case of a 49-year-old male patient who underwent sequential procedures for hemorrhoids and perianal abscess.

Understanding the toxicity risk of antibiotic emissions of aquaculture from the perspective of fluctuations concentration.

Organisms are generally exposed to target contaminant with stable concentrations in traditional ecotoxicological studies. However, it is difficult to truly represent the dynamics and complexity of actual aquatic pollution for risk management. Contaminants may enter nearby aquatic systems in pulsed exposure, thus resulting in that aquatic organisms will be exposed to contaminants at fluctuating concentrations.

SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis.

Background: Aberrant alternative splicing (AS) is a pervasive event during colorectal cancer (CRC) development. SF3B3 is a splicing factor component of U2 small nuclear ribonucleoproteins which are crucial for early stages of spliceosome assembly. The role of SF3B3 in CRC remains unknown.

Tuning Redistribution of CuO Nanoparticles on TiO Support.

Nanoparticles exhibit unique catalytic performance, depending on their nanoscale size. However, controlling the particle size of the supported catalysts is still challenging. Here, we present a method for tunable redistribution of CuO nanoparticles on rutile TiO support by physically adding pristine TiO.

Understanding the Role of Base Species on Reversed Cu Catalyst in Ring Opening of Furan Compounds to 1, 2-Pentanediol.

The hydrogenation of biomass-derived furan compounds provides a sustainable pathway for the production of various valuable chemicals; product selectivity among multiple reaction pathways of furan compound hydrogenation is crucially dependent on catalytic sites; however controlling reaction pathways remains challenging due to the lack of identification and understanding of active sites. In this work we reveal the role of base sites in furfural selective hydrogenation through deliberately designed and synthesized reversed catalysts, basic metal oxides and hydroxide on Cu. It is demonstrated that base species greatly enhanced the selectivity of 1, 2-pentanediol (1, 2-PeD) from furfural, presenting a nearly fourfold increase of 1, 2-PeD: methyl furan ratio over the Cu based reverse catalysts.

Selective synthesis of -phenols from bio-benzoic acids via regulating the adsorption state.

Phenols are important building blocks widely applied in many fields. The pronounced orientational effect of the phenolic hydroxyl group makes achieving selective synthesis of -phenols challenging. Accessing -phenols needs lengthy synthetic sequences.

Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.

This study was to investigate the potential mechanism of triptolide-induced hepatotoxicity. We found a novel and variable role of p53/Nrf2 crosstalk in triptolide-induced hepatotoxic process. Low doses of triptolide led to adaptive stress response without obvious toxicity, while high levels of triptolide caused severe adversity.

Shunaoxin dropping pill improves cognitive functions of rats with chronic cerebral hypoperfusion via the microbiota-gut-brain axis.

Chronic cerebral hypoperfusion (CCH) is a major risk factor for cognitive decline and degenerative processes. Shunaoxin dropping pill (SNX) has been clinically used to treat cerebrovascular diseases. However, the effect and mechanism of SNX in treating CCH-induced cognitive impairment remain unclear.

The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression.

Estrogen receptor α (ERα) is the most common clinical marker used for breast cancer prognosis and the classification of breast cancer subtypes. Clinically, patients with estrogen receptor-positive breast cancer can receive endocrine therapy. However, resistance to endocrine therapy has become an urgent clinical problem.

3D-QSAR analysis of the interactions of flavonoids with human organic cation transporter 2.

Flavonoids are a class of phenolic and polyphenolic compounds widely distributed in vegetables, fruits, grains and herbs. Organic cation transporter 2 (OCT2) mediates the renal secretion of organic cations and is a key site of drug-drug interactions (DDIs). In this study, we systematically investigated the inhibitory effect of 28 flavonoids on OCT2-mediated uptake of 4-4-dimethylaminostyryl-N-methylpyridinium (ASP).

Alveolar soft tissue sarcoma: a report of 50 cases at a single institution.

Background: Alveolar soft-part sarcoma (ASPS) is a rare soft tissue sarcoma subtype, occurring mainly in young people, with poor prognosis.

Materials And Methods: We conducted a retrospective analysis of localized or metastatic ASPS patients admitted to the First Affiliated Hospital of Zhengzhou University (China) from 2012 to 2020, focusing on treatment and prognosis.

Results: The median age at diagnosis was 24 years (range: 1.

Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome.

Background: The tumor suppressor gene is the most commonly mutated gene in human cancers. Humans who inherit mutant alleles develop a wide range of early onset cancers, a disorder called Li-Fraumeni Syndrome (LFS). -deficient mice recapitulate most but not all of the cancer phenotypes observed in -deficient human cancers, indicating that new animal models may complement current mouse models and better inform on human disease development.

The neural basis of decision-making during time-based inter-role conflict.

Time-based inter-role conflict is a type of conflict in which individuals are faced with simultaneous role pressures from different role domains. Some researchers have applied a decision-making perspective to investigate inter-role conflict; however, the neural basis of inter-role decision-making has rarely been discussed. In the current study, a collection of inter-role conflict scenarios with high/low levels of conflict were selected, and sixty college students were recruited to make choices between the conflicting student and family/friend demands in each scenario while their brain activities were recorded using functional magnetic resonance imaging.

Mechanism of the inhibition and detoxification effects of the interaction between nanoplastics and microalgae Chlorella pyrenoidosa.

Most previous studies have focused on the toxicity of microplastics on aquatic organisms. However, research on nanoplastics is still limited and poses significant threat to aquatic organisms than microplastics. Therefore, this study investigated the effects of nanoplastics (80 nm) on the microalgae Chlorella pyrenoidosa.

Rapid visual detection of gene expression in sheep.

Sheep play an important role in agricultural production and people's lives, and fecundity is one of the most important economic traits of sheep for sheep breeders. The Booroola fecundity () gene has a certain correlation with litter size in sheep. Therefore, this study aims to detect expression quickly, accurately and visually.

Neural processing of the physical attractiveness stereotype: Ugliness is bad vs. beauty is good.

The physical attractiveness stereotype (PAS) is characterized by the belief that beauty is good and ugliness is bad. Although the belief is not encouraged, people still express "beauty is good" explicitly. However, expressing that ugliness is bad is considered impolite in public.

Integrated Analysis of a Risk Score System Predicting Prognosis and a ceRNA Network for Differentially Expressed lncRNAs in Multiple Myeloma.

Long non-coding RNAs (lncRNAs) are non-protein-coding RNAs longer than 200 nucleotides. Accumulating evidence demonstrates that lncRNA is a potential biomarker for cancer diagnosis and prognosis. However, there are no prognostic biomarkers and lncRNA models for multiple myeloma (MM).

Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway.

Ethnopharmacological Relevance: Physalis Calyx seu Fructus is typically used to treat inflammatory diseases such as upper respiratory tract infection and acute tonsillitis in clinical practice of China. Physalin A, a main active ingredient of this traditional Chinese medicine (TCM), has been reported for its significant anti-tumor activity. However, most reports focused on the studies of its anti-tumor activity, the anti-inflammatory activity of physalin A and its molecular mechanism are still not elucidated clearly.

Expression Profile Analysis of m6A RNA Methylation Regulators Indicates They Are Immune Signature Associated and Can Predict Survival in Kidney Renal Cell Carcinoma.

N6-Methyladenosine (m6A) refers to the methylation modification occurring at the nitrogen-6 position of adenosine. Many human physiological processes such as modulation of spermatogenesis are caused by m6A RNA modifications. However, the relationship between m6A RNA methylation regulators and kidney renal clear cell carcinoma (KIRC) remains rarely investigated.

TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of β-catenin.

Purpose: TRAF4 plays an important role in the development and progression of breast cancer, but its impact on chemotherapy resistance is as yet, however, poorly understood.

Methods: Western blotting, immunoprecipitation, and immunofluorescence staining were used to identify and verify that TRAF4 was a novel substrate of SIAH1 and prevented SIAH1-mediated β-catenin degradation. Cell proliferation analysis and Flow cytometry analysis were utilized to detect TRAF4's function on the growth-inhibitory effect of etoposide.

Circular RNA circ-ZEB1 acts as an oncogene in triple negative breast cancer via sponging miR-448.

Background: Circular RNAs (circRNAs) play an important role in tumor development. The miRNA sponge is a common role played by circRNAs in various tumors, including breast cancer.

Objective: This study aimed to explore the role of circ-ZEB1 in the proliferation and apoptosis of triple negative breast cancer (TNBC) cells.