The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation.

Background: NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4 T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4IL22IFNγIL17A) cells are a subgroup of CD4 effector T cells that primarily generate IL-22.