Differentiate Clinical Characteristics Between Viral Pneumonia and Mycoplasma pneumoniae and Nomograms for Predicting Mycoplasma pneumoniae : A Retrospective Study in Primary Hospitals.

Objective: To identify the difference in clinical characteristics between viral pneumonia and Mycoplasma pneumoniae , providing cues on their differential diagnosis for primary hospitals with the insufficient pathogen detection capacity.

Methods: We retrospectively reviewed the medical records of hospitalized children with acute respiratory tract infections, and pathogenic microbes test results were analyzed. Clinical characteristics, routine blood parameters and hospitalization duration and fee were compared between M.

New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242.

Four new compounds, asperisocoumarin G (1), asperisocoumarin H (2), (±)-asperisocoumarin I [(±)-3], along with the known pergillin (4) and penicisochroman L (5) were isolated from a mangrove endophytic fungus Aspergillus sp. 085242 by further chemical investigation. The structures of the new compounds, including their absolute configurations, were established by analysis of HR-ESI-MS and NMR spectroscopic data, and ECD calculation.

Isobenzofuranone monomer and dimer derivatives from the mangrove endophytic fungus Epicoccum nigrum SCNU-F0002 possess α-glucosidase inhibitory and antioxidant activity.

Four new isobenzofuranone monomers, (+)-epicoccone C ((+)-1), (-)-epicoccone C ((-)-1), epicoccone D (2), epicoccone E (3) and one new isobenzofuranone dimer, epicolactone A (4), together with four known related dimers were obtained from the fermentation of an endophytic fungus, Epicoccum nigrum SCNU-F0002, which was isolated from the fresh fruit of the mangrove plant Acanthus ilicifolius L. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. These isolated compounds (1-8) were evaluated for their antioxidant activity and α-glucosidase enzyme inhibitory activity.

Ophiobolin-Type Sesterterpenoids from the Mangrove Endophytic Fungus sp. ZJ-68.

Eleven new ophiobolin-type sesterterpenoids, asperophiobolins A-K (-), along with 12 known analogues (-) were isolated from the cultures of the mangrove endophytic fungus sp. ZJ-68. The structures of the new compounds were elucidated through spectroscopic analyses, and their absolute configurations were assigned by a combination of Mo(AcO)-induced electronic circular dichroism spectra and quantum chemical calculations.

The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus SCNU-F0002.

Six new polyketides, including one coumarin (), two isocoumarins ( and ), dihydroradicinin (), and two benzofuranone derivatives ( and ), together with seven known analogues (- and -) were isolated from the culture of the mangrove endophytic fungus SCNU-F0002. The structures were elucidated on the interpretation of spectroscopic data. The absolute configuration of Compounds and were determined by comparison of their ECD spectra with the data of their analogue dihydroisocoumarins described in the literature.

Thiocladospolide E and cladospamide A, novel 12-membered macrolide and macrolide lactam from mangrove endophytic fungus Cladosporium sp. SCNU-F0001.

Chemical investigation of the mangrove endophytic fungus Cladosporium sp. SCNU-F0001 resulted in the isolation and identification of a new macrolide compound named thiocladospolide E (1) and a novel macrolide lactam named cladospamide A (2), along with the known cladospolide B (3). The structures were elucidated based on spectroscopic methods, and the absolute configurations were determined by X-ray diffraction and HPLC analysis after chemical derivatization.

Two new secondary metabolites from the mangrove endophytic fungus SK7.

Two new compounds, an abscisic acid-type sesquiterpene (), and one asterric acid derivative (), together with three known compounds () were isolated from mangrove endophytic fungus SK7. The structures of these metabolites were determined by NMR, X-ray crystal diffraction, CD and HR-ESI-MS. All compounds were tested for their antibacterial, antioxidant and cytotoxic activities, among these compounds, showed cytotoxicity against MDA-MB-435 cell with an IC of 25.