Publications by authors named "Huixian Cheng"
Network pharmacology and molecular docking to explore the potential mechanism of chlorogenic acid in septic acute liver injury and experimental validation of TLR4/NF-κB pathway in vivo.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
The objective of this study was to investigate the biological activities and mechanisms of chlorogenic acid (CGA) in the treatment of septic acute liver injury (SALI) based on the network pharmacology, molecular docking, in vivo studies, and other techniques. Chlorogenic acid and potential related targets of septic acute liver injury were searched from the public databases. Then, the protein-protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted.
View Article and Find Full Text PDFAzithromycin induces liver injury in mice by targeting the AMPK/Nrf2 pathway.
Immunopharmacol Immunotoxicol
December 2024
Article Synopsis
- Azithromycin is used to treat various infections in children but may cause liver damage, and its exact action mechanism is unknown.
- The study aimed to understand the molecular basis of azithromycin-induced liver injury to improve treatment strategies.
- Findings reveal that azithromycin leads to increased liver cell death and oxidative stress, and its harmful effects may stem from the suppression of protective pathways in the liver.
Article Synopsis
- The study explored the combined toxicity effects of sodium fluoride (NaF) and microplastics (MPs) on testicular Sertoli cells in male mice, which hasn't been previously investigated.
- Results showed that exposure to both NaF and MPs simultaneously increased reproductive toxicity, leading to structural defects in testes, impaired sperm production, and increased cell death in Sertoli cells.
- The research highlighted that NaF and MPs work together to worsen testicular damage and dysfunction, providing important insights into how these substances may interact as environmental pollutants.
Objective: The aim of the study was to determine if migraine is associated with fetal-type posterior cerebral artery (PCA) in patients with ischemic stroke.
Method: In this cross-sectional study, patients with acute ischemic stroke were enrolled from two hospitals. The history of migraine headache was evaluated during a face-to-face interview.
Objective: To explore the application value and effect of distance live broadcast in Clinical Anesthesiology teaching.
Methods: Undergraduate students of year 2017 who majored in Anesthesiology at the Wannan Medical College (China) were chosen as the study subjects. According to the different teaching methods, the students were divided into two groups: 59 in the traditional teaching group (control group) and 61 in the traditional teaching combined with distant live broadcasting teaching group (observation group).
Endotoxin-induced lung injury is one of the major causes of death induced by endotoxemia, however, few effective therapeutic options exist. Hydrogen inhalation has recently been shown to be an effective treatment for inflammatory lung injury, but the underlying mechanism is unknown. In the current study we aim to investigate how hydrogen attenuates endotoxin-induced lung injury and provide reference values for the clinical application of hydrogen.
View Article and Find Full Text PDFObjective: To investigate the effects of mild hypothermia on the expression of ASIC1a and ASIC2a in the rat hippocampus following global cerebral ischemia-reperfusion, so as to speculate the underlying mechanisms of neuroresuscitation.
Methods: Ninety five male SD rats were randomly divided into five groups (n = 19): sham operation group (I), model group (II), mild hypothermia group (III), PcTX1 group (IV), mild hypothermia combined PcTX1 group (V). Transient (15 min) global cerebral ischemia was induced by the four-vessel occlusion.