Publications by authors named "Huixian Chang"

Extracellular vesicles (EVs) are abundant in reproductive tract fluids and serve as important mediators of paracrine communication, influencing the function of gametes. Sperm undergo development in the male reproductive tract and exert their function within the female reproductive tract, engaging in interactions with various types of EVs present throughout the reproductive system. Previous studies have demonstrated that both male and female reproductive tract EVs can impact sperm function by transferring regulatory cargoes to them.

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Postoperative neurocognitive impairment is an urgent problem with global aging accelerating. The prevention and treatment of postoperative neurocognitive impairment have been widely investigated but lack effective strategies. Low-intensity pulsed ultrasound (LIPUS), a non-invasive tool, has shown an effect on neuroprotection, but whether it could attenuate the postoperative neurocognitive impairment and the underlying mechanisms remains unknown.

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Low-intensity ultrasound (LI-US) is a non-invasive stimulation technique that has emerged in recent years and has been shown to have positive effects on neuromodulation, fracture healing, inflammation improvement, and metabolic regulation. This study reports the conclusions of a bibliometric analysis of LI-US. Input data for the period between 1995 and 2022, including 7209 related articles in the field of LI-US, were collected from the core library of the Web of Science (WOS) database.

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Article Synopsis
  • Postoperative neurocognitive disorders (po-NCDs), such as postoperative delirium (POD) and delayed neurocognitive recovery (dNCR), frequently affect older surgical patients, but reliable biomarkers to predict these risks are still not established.
  • This study utilized proteomic analysis to identify abnormal protein levels in key brain regions of aged rats with dNCR, confirming the presence of specific proteins through additional testing methods, like western blotting and PCR.
  • The findings revealed potential biomarkers, including increased haptoglobin and alpha-2 macroglobulin, and decreased 14-3-3β/α, which were also validated in serum samples from elderly hip fracture patients, suggesting new avenues for diagnosing and studying po-N
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