Publications by authors named "Huiwu Xing"

Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous tumor and a primary cause of cancer-relevant deaths worldwide. The role of reactive oxygen species (ROS) in HCC development is less studied.

Methods: Seurat package and CellMarker database were employed for single-cell RNA sequencing (scRNA-seq) analysis based on the GSE189175 dataset from Gene Expression Omnibus (GEO).

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  • * Conducted in Chongqing, China, the research involved 158 infants and measured levels of SARS-CoV-2 IgG and neutralizing antibodies, finding those born to vaccinated mothers with breakthrough infections had the highest antibody levels.
  • * Results indicated that antibody levels declined with infant age but persisted for about four months, highlighting the importance of maternal vaccination for better infant immunity against COVID-19.
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In recent years, development in high-throughput sequencing technologies has experienced an increasing application of statistics, pattern recognition, and machine learning in bioinformatics analyses. SangeBox platform to meet different scientific demands. The new version of Sangs is a widely used tool among many researchers, which encourages us to continuously improve the plerBox 2 (http://vip.

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  • - The study investigates how hepatocellular carcinoma (HCC) interacts with cirrhosis to worsen liver conditions and promote cancer progression, highlighting the need for better treatment strategies.
  • - Researchers analyzed RNA-sequencing data from The Cancer Genome Atlas (TCGA) to identify gene modules associated with cirrhosis, discovering two significant gene groups (MEbrown and MEgreen) linked to immune and malignant cells, respectively.
  • - The findings suggest that immune and malignant cells are key players in fibrosis development, showing close spatial relationships in HCC tissues, which may enhance our understanding of how liver fibrosis progresses in patients with cirrhosis and HCC.
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  • 5-Methylcytosine (m5C) RNA modification, mediated by NSUN2, is crucial for regulating cancer biology, but its specific role in hepatocellular carcinoma (HCC) was previously unclear.
  • This study revealed that higher levels of NSUN2 in HCC correlate with worse patient outcomes, linking NSUN2 with tumor immune regulation and aggressive cancer traits like growth and invasion.
  • Notably, NSUN2 influences HCC cell behavior through the Wnt signaling pathway and its target SARS2, highlighting its role in promoting cancer progression via m5C RNA modifications.
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For end-stage liver disease in children, living donor liver transplantation (LDLT) is often the important standard curative treatment. However, there is a lack of research on early recovery of graft function after pediatric LDLT. This is a single-center, ambispective cohort study.

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The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various types of cancer. Recently, epigenetic modifications, particularly N6-methyladenosine (m6A), have been recognized as essential contributors to mRNA-related biological processes and translation.

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Background: Hepatocellular carcinoma (HCC) is one of the most common cancers in the digestive system with rapid progression and poor prognosis. Recent studies have shown that RPL27A could be used as a biomarker for a variety of cancers, but its role in HCC is not clear.

Method: We analyzed the expression of RPL27A in the pan-cancer analysis and analyzed the relationship between the expression of RPL27A and the clinical features and prognosis of patients with HCC.

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Objective: To analyze the incidence trend and establish a model to predict the prognosis of hepatic malignant tumors in children (CHMTs).

Methods: We analyzed the incidence data of CHMTs from 1975 to 2018 from the Surveillance, Epidemiology, and End Results (SEER) database, and evaluated the incidence trends based on different demographic and pathological features. We also analyzed clinicopathologic data from 2000 to 2018 from the SEER database.

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The coronavirus disease 2019 (COVID-19) vaccine generates functional antibodies in maternal circulation that are detectable in infants, while the information is restricted to the usage of COVID-19 vaccine during pregnancy. In this study, we aimed to evaluate the effect of maternal COVID-19 vaccines before pregnancy. Infants were included from mothers with no inactivated COVID-19 vaccine, 1-, 2-, and 3-dose before pregnancy, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies were tested.

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The relationship between lead exposure and neurological disorders has been extensively studied, but the effects of lead exposure on hepatotoxicity are unknown. Metabolically related fatty liver disease (MAFLD) is an update of previous non-alcoholic fatty liver disease (NAFLD). It redefines the diagnostic conditions and emphasizes metabolic factors while considering non-alcoholic factors.

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Background: Liver transplantation (LT) is one of the most important treatments for children with liver cancer (CLCa) and has been increasingly used. However, there is a lack of large-scale and multicenter studies on the trend in the application and value of LT for the treatment of CLCa.

Methods: We analyzed the clinicopathological data of CLCa from 2000 to 2018 from the Surveillance, Epidemiology, and End Results (SEER) database.

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Rationale: In clinical practice, foreign bodies (FBs) in the digestive tract are more common in children, but intrahepatic FBs are rare, especially those that can cause infection, bleeding, bile leakage, and other complications. However, there is no consensus on its diagnosis and treatment due to the lack of large-scale cohort studies.

Patient Concerns: Case 1 is a 4-years 8-months-old girl, who at the age of 10 months, showed an X-ray finding of a striped FB in her liver, with no symptoms.

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Background: The incidence of hepatic artery thrombosis in pediatric living donor liver transplantation (LDLT) is significantly higher than that in adults, and is closely related to the surgeon's experience with hepatic artery anastomosis. However, there are few studies on the learning curve of hepatic artery anastomosis among surgeons.

Methods: We collected data related to 75 patients who underwent pediatric LDLT and hepatic artery anastomosis independently by the same surgeon.

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Background: Biliary atresia (BA) is a serious biliary disease in infancy. Jaundice is the most visual and prominent symptom, and it mainly involves bile duct cells leading to the loss of intrahepatic and extrahepatic bile ducts. If left untreated, it will eventually progress to liver cirrhosis.

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Background: Intrahepatic cholangiocarcinoma (ICCA) is a primary liver cancer characterized by rapid progression and poor prognosis. There are few effective tools for evaluating the prognosis of ICCA patients, and the use of liver transplantation (LT) of the treatment for ICCA is still controversial.

Methods: We analyzed ICCA incidence data and clinicopathological data from the Surveillance, Epidemiology, and End Results database.

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LncRNA MNX1 antisense RNA 1 (MNX1-AS1) is significantly overexpressed in patients with bladder cancer, suggesting that it might be associated with bladder cancer. However, the molecular mechanism of MNX1-AS1 in bladder cancer remained indistinct. To illustrate the role of MNX1-AS1 in bladder cancer, the gain- and loss-of-function experiments were conducted in bladder cancer cells.

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