Cu-Tremella fuciformis polysaccharide-based tumor microenvironment-responsive injectable gels for cuproptosis-based synergistic osteosarcoma therapy.

Cuproptosis affects osteosarcoma locally, and the exploitation of cuproptosis-related biomaterials for osteosarcoma treatment is still in its infancy. We designed and synthesized a novel injectable gel of Cu ion-coordinated Tremella fuciformis polysaccharide (TFP-Cu) for antiosteosarcoma therapy. This material has antitumor effects, the ability to stimulate immunity and promote bone formation, and a controlled Cu release profile in smart response to tumor microenvironment stimulation.

Calcitriol-Loaded Multifunctional Nanospheres with Superlubricity for Advanced Osteoarthritis Treatment.

Osteoarthritis (OA) is characterized by the lubrication dysfunction of a cartilage sliding interface caused by chronic joint inflammation, and effective nonsurgical therapy for advanced OA remains lacking. Addressing chronic joint inflammation, lubrication dysfunction, and cartilage-tissue degradation simultaneously may hopefully tackle this challenge. Herein, we developed superlubricative zein@alginate/strontium@calcitriol (ZASC) nanospheres to treat advanced OA.

circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations.

Gastric cancer has been one of the wide public health burdens with its high morbidity and mortality over several decades. As the unconventional modules among RNA families, circular RNAs present their blazing biological effects during gastric carcinogenesis. Though diverse hypothetical mechanisms were reported, further tests were necessitated for authentication.

Effect of Chemoradiotherapy on the Survival of Resectable Gastric Cancer Patients: A Systematic Review and Meta-Analysis.

Background: Adjuvant chemotherapy (CT) and chemoradiotherapy (CRT) after surgery are necessary to reduce the risk of metastasis and recurrence for resectable gastric cancer (GC) patients. Adjuvant CT and CRT have been proven to significantly improve the prognosis for GC patients, when compared with surgery only. However, it is still unclear whether radiotherapy offers additional survival benefits to advanced gastric cancer (AGC) patients.

Pyroptosis is related to immune infiltration and predictive for survival of colon adenocarcinoma patients.

Pyroptosis is a novel type of programmed cell death, initiated by inflammasome. Pyroptosis inhibits the development and metastasis of colon cancer and is associated with patients' prognosis. However, how the pyroptosis-related genes predict the survival of patients is still unclear.

Central lymph node metastasis is predictive of survival in advanced gastric cancer patients treated with D2 lymphadenectomy.

Background: The number of positive lymph nodes, which was defined as "N stage", is mostly used to predict the survival of D2-resected gastric cancer patients, not the location. A "central lymph node" (CnLN) was defined by Ikoma et al., included common hepatic, celiac and proximal splenic artery LNs.

Different clinicopathologic features and prognostic significance of signet ring cell histology in early and locally advanced gastric cancer patients.

Background: Although many studies have evaluated the prognostic significance of signet ring cell (SRC) histology for gastric cancer (GC) patients, the results were conflicting. The objective of this study was to compare clinicopathologic characteristics between SRC type and other types, and evaluate its impact on survival outcome.

Methods: We retrospectively reviewed clinicopathologic and survival data of 1891 patients who underwent curative resection for GC.

Risk of lymph node metastasis and prognostic outcome in early gastric cancer patients with mixed histologic type.

Background: Whether early gastric cancer with mixed histologic type should be considered for endoscopic submucosal dissection (ESD) remains controversial. The objective of this study was to evaluate the risk of lymph node metastasis (LNM) and prognostic significance for early gastric cancer with mixed histologic type.

Methods: We retrospectively reviewed clinicopathologic and survival data of 302 patients who underwent surgical resection for early gastric cancer.

Impact of Lymphovascular Invasion on Survival Outcome in Patients With Gastric Cancer.

Objectives: To evaluate the prognostic significance of lymphovascular invasion (LVI) for patients with gastric cancer (GC).

Methods: A total of 1,720 consecutive patients who underwent curative gastrectomy were retrospectively identified. The association between LVI and clinicopathologic characteristics was determined and its impact on survival outcome was evaluated.

Clinicopathological features, risk of lymph node metastasis and survival outcome of synchronous multiple early gastric cancer.

Objective: To determine clinicopathological features, risk of lymph node metastasis (LNM) and survival outcome in synchronous multiple early gastric cancer (MEGC) patients.

Methods: A total of 338 solitary early gastric cancer (SEGC) and 26 MEGC patients who underwent surgical resection were retrospectively reviewed. The clinicopathological features and predictive factors for MEGC patients were evaluated.

Clinicopathologic Features, Survival Outcome, and Prognostic Factors in Gastric Cancer Patients 18-40 Years of Age.

Whether young patients with gastric cancer (GC) had a distinct prognostic outcome from older patients remains controversial. The objective of this study was to investigate the clinicopathologic characteristics and prognostic factors of young GC patients and evaluate the survival outcome in comparison to their older counterparts. We retrospectively reviewed clinicopathologic and survival data of 2022 patients who underwent curative resection for GC.

Does delayed initiation of adjuvant chemotherapy following the curative resection affect the survival outcome of gastric cancer patients: A systematic review and meta-analysis.

Background: Adjuvant chemotherapy(AC) following the curative resection could improve the survival outcome of advanced gastric cancer(GC) patients. However, there is no specific timing interval from radical surgery to initiation of AC. Whether delayed initiation of AC could affect the survival outcome of these patients remains unclear.

Impact of proximal resection margin involvement on survival outcome in patients with proximal gastric cancer.

Aim: The aim of this study was to evaluate the risk factors for proximal resection margin involvement and its impact on survival outcome in patients with proximal gastric cancer.

Methods: A total of 488 patients who underwent potentially curative resection for proximal gastric cancer were retrospectively reviewed. Clinicopathological characteristics and survival differences between patients with positive and negative resection margins were compared and prognostic factors were determined by Cox multivariate analysis.

Impact of skip lymph node metastasis on the prognosis of gastric cancer patients who underwent curative gastrectomy.

Purpose: Skip metastasis (SK) is an exceptional pattern of lymph node metastasis and the incidence of skip metastasis is not infrequent in gastric cancer (GC). In the present study, we evaluated the clinical significance of skip LN metastasis in GC patients.

Methods: According to the anatomical location of positive lymph nodes (LNs), the patients who underwent curative gastrectomy in our institute were classified in three groups: only perigastric involvement (PG group), only extraperigastric involvement (SK group) and both perigastric and extraperigastric involvement (PG+EP group).

Feasibility of laparoscopy gastrectomy for gastric cancer in the patients with high body mass index: A systematic review and meta-analysis.

The aim of this study was to evaluate the impact of high body mass index (BMI) on surgical outcome of laparoscopic gastrectomy for gastric cancer (GC). Systematic literature search was performed using PubMed and Embase databases. The relevant data were extracted, and surgical outcomes and postoperative complications were compared between BMI≥25 kg/m and BMI<25 kg/m group using a fixed effect model or random effect model.

Does Helicobacter pylori Eradication Reduce the Incidence of Metachronous Gastric Cancer After Curative Endoscopic Resection of Early Gastric Cancer: A Systematic Review and Meta-Analysis.

Background: Whether Helicobacter pylori eradication could reduce the risk of metachronous gastric cancer remain controversial. In the present study, we performed a systematic review and meta-analysis to evaluate the preventive effect of H. pylori eradication on the occurrence of metachronous gastric cancer after curative endoscopic resection of early gastric cancer.

Clinicopathologic factors associated with recurrence and long-term survival in node-negative advanced gastric cancer patients.

Background: despite a better prognosis in node-negative advanced gastric cancer (GC), a proportion of patients have a tumor recurrence within five years and eventually die due to cancer-related causes. The present study aimed to evaluate the predictive factors of tumor recurrence and long-term survival in node-negative advanced GC.

Methods: a total of 646 node-negative advanced GC patients who underwent a curative gastrectomy in our institution were included in the study.

Does high body mass index negatively affect the surgical outcome and long-term survival of gastric cancer patients who underwent gastrectomy: A systematic review and meta-analysis.

Background: Whether high body mass index (BMI) was associated with increased postoperative complications and unfavorable prognosis of gastric cancer (GC) patients remain controversial. In the present study, we performed a systematic review and meta-analysis to evaluate the impact of high BMI on surgical outcome, postoperative complications and long-term survival of GC patients.

Methods: The related studies were identified by searching PubMed and Embase databases.

Picosecond nonlinear optical properties of SrTiO composite films doped with gold and nickel nanoparticles.

Nanoparticles composite thin films formed by nanometer-sized gold and nickel particles embedded in SrTiO matrices were fabricated on MgO single-crystal substrates by co-depositing the metal and ceramic targets using the pulsed laser deposition technique. The linear optical absorption properties were measured from 350 to 800 nm, and the absorption peak due to the surface plasmon resonance of Au metal particles was observed around 557 nm. The ultra-fast third-order nonlinear optical properties of the films were determined by a single-beam z-scan method at a wavelength of 532 nm with laser duration of 55 ps.

[Effect of pomegranate peel extracts on oxidative stress in restrained mice].

Objective: To observe the protective effects of pomegranate peel extracts on oxidative stress in restrained mice.

Methods: The liver injury model was established under 18 h restraint stress in mice. The protective effects were evaluated by assessing alanine aminotransferase (ALT) GSH and Malondialdehyde (MDA) levels in plasma and antioxidant capacities of liver were measured by using oxygen radical absorbance capacity (ORAC) assay.

[Anti-allergic effects of Rubus suavissimus extract].

Objective: To investigate the effects of Rubus suavissimus S. Lee extract (RSE) on mice, and its influence on release of histamine from rat peritoneal mast cells induced by compound 48/80 in vitro.

Methods: To establish murine delayed-type-hypersensitive model induced by 2,4-dinitrofluotobenzene (DNFB) and sheep red blood cell (SRBC); murine type I allergic reaction induced by PCA, and then to observe the anti-allergic effect of RSE.

[Determination of curculigoside in crude medicine Curculigo orchioides by HPLC].

Objective: To establish a method for the determination of curculigoside in Curculigo orchioides, a species of crude medicine.

Method: The methanol was used as the solvent of exatraction and the curculigoside was extracted from the crude medicine with the method of the ultrasonic vibration. Using Sep-Pak C18 cartridges to purify the solution, the curculigoside was detected by HPLC.