Boosting CO photoreduction over perovskite quantum dots decorated with dispersed ruthenium nanoparticles.

High efficiency CO conversion materials are ideal for solar to carbon fuel conversion. Halide perovskite quantum dots (QDs) are highly desirable as catalysts and have been extensively investigated in the field of CO photoreduction. The major challenge lies in the severe charge recombination and the weak ability to activate CO.

Synthesis of Mn-doped hollow octahedron ZnInS to enhance photocatalytic hydrogen production performance utilizing metal-organic framework as template.

Designing semiconductor photocatalysts with unique structures can improve the transfer efficiency of solar energy to hydrogen (H). In this study, a dual modification method of element doping and morphological control was used. The Mn-doped hollow octahedron ZnInS (ZHO-Mn) was synthesized by a simple one-pot solvothermal method using the octahedral Mn-based metal-organic framework (Mn-MOF) as a template.

Hollow core-shell heterojunction TAPB-COF@ZnInS as highly efficient photocatalysts for carbon dioxide reduction.

The conversion of carbon dioxide (CO) into carbon-neutral fuels using solar energy is crucial for achieving energy sustainability. However, the high carrier charge recombination and low CO adsorption capacity of the photocatalysts present significant challenges. In this paper, a TAPB-COF@ZnInS-30 (TAPB-COFZ-30) heterojunction photocatalyst was constructed by growth of ZnInS (ZIS) on a hollow covalent organic framework (HCOF) with a hollow core-shell structure for CO to CO conversion.

Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.

Diabetic cardiomyopathy (DCM), a severe complication of diabetes, is characterized by mitochondrial dysfunction, oxidative stress, and DNA damage. Despite its severity, the intrinsic factors governing cardiomyocyte damage in DCM remain unclear. It is hypothesized that impaired iron-sulfur (Fe-S) cluster synthesis plays a crucial role in the pathogenesis of DCM.

RRP8, associated with immune infiltration, is a prospective therapeutic target in hepatocellular carcinoma.

Background: Ribosomal RNA Processing 8 (RRP8) is a nucleolar Rossman fold-like methyltransferase that exhibits increased expression in many malignant tumours. However, the role of RRP8 in hepatocellular carcinoma (HCC) is still uncertain. We explored the relationships between RRP8 and prognosis and immune infiltration, as well as the putative pathological function and mechanism of RRP8 in HCC.

A machine learning model identifies M3-like subtype in AML based on PML/RARα targets.

The typical genomic feature of acute myeloid leukemia (AML) M3 subtype is the fusion event of PML/RARα, and ATRA/ATO-based combination therapy is current standard treatment regimen for M3 subtype. Here, a machine-learning model based on expressions of PML/RARα targets was developed to identify M3 patients by analyzing 1228 AML patients. Our model exhibited high accuracy.

In situ Mo-doped ZnInS/Ni-Ni Hofmann-type coordination polymer composites for photocatalytic hydrogen evolution reaction.

Solar energy-assisted hydrogen production technology is an essential tool for exploring hydrogen energy. To date, semiconductors have been used as the primary photocatalyst to generate hydrogen via photocatalytic water splitting. However, the high photogenerated electron-hole recombination rate of semiconductor photocatalysts results in a low hydrogen production rate.

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

Trimethylation of histone H3 lysine 9 (H3K9me3) is crucial for the regulation of gene repression and heterochromatin formation, cell-fate determination and organismal development. H3K9me3 also provides an essential mechanism for silencing transposable elements. However, previous studies have shown that canonical H3K9me3 readers (for example, HP1 (refs.

One-Step MOF-Templated Strategy to Fabrication of Ce-Doped ZnIn S Tetrakaidecahedron Hollow Nanocages as an Efficient Photocatalyst for Hydrogen Evolution.

Achieving structure optimizing and component regulation simultaneously in the ZnIn S -based photocatalytic system is an enormous challenge in improving its hydrogen evolution performance. 3D hollow-structured photocatalysts have been intensively studied due to their obvious advantages in solar energy conversion reactions. The synthesis of 3D hollow-structured ZnIn S , however, is limited by the lack of suitable template or synthesis methods, thereby restricting the wide application of ZnIn S in the field of photocatalysis.

DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.

DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk. Here, we report that DNA methyltransferase 1 (DNMT1) specifically 'recognizes' H4K20me3 via its first bromo-adjacent-homology domain (DNMT1).

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.

Trimethylation of histone H3 lysine 27 (H3K27me3) is important for gene silencing and imprinting, (epi)genome organization and organismal development. In a prevalent model, the functional readout of H3K27me3 in mammalian cells is achieved through the H3K27me3-recognizing chromodomain harbored within the chromobox (CBX) component of canonical Polycomb repressive complex 1 (cPRC1), which induces chromatin compaction and gene repression. Here, we report that binding of H3K27me3 by a Bromo Adjacent Homology (BAH) domain harbored within BAH domain-containing protein 1 (BAHD1) is required for overall BAHD1 targeting to chromatin and for optimal repression of the H3K27me3-demarcated genes in mammalian cells.

BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis.

Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate determination and differentiation. We report that a conserved bromo-adjacent homology (BAH) module of BAHCC1 (BAHCC1) 'recognizes' H3K27me3 specifically and enforces silencing of H3K27me3-demarcated genes in mammalian cells. Biochemical, structural and integrated chromatin immunoprecipitation-sequencing-based analyses demonstrate that direct readout of H3K27me3 by BAHCC1 is achieved through a hydrophobic trimethyl-L-lysine-binding 'cage' formed by BAHCC1, mediating colocalization of BAHCC1 and H3K27me3-marked genes.

Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.

In mammals, repressive histone modifications such as trimethylation of histone H3 Lys9 (H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced chromatin state. However, it remains elusive how these epigenetic modifications crosstalk. Here, through structural and biochemical characterizations, we identified the replication foci targeting sequence (RFTS) domain of maintenance DNA methyltransferase DNMT1, a module known to bind the ubiquitylated H3 (H3Ub), as a specific reader for H3K9me3/H3Ub, with the recognition mode distinct from the typical trimethyl-lysine reader.

Metal-Organic Framework-Derived p-CuO/n-Ce-FeO Heterojunction Nanorod Photoanode Coupling with a FeOOH Cocatalyst for High-Performance Photoelectrochemical Water Oxidation.

Rapid charge recombination and slow water oxidation kinetics are key drawbacks that limit the photoelectrochemical water splitting efficiency of FeO. In this work, we designed and fabricated for the first time that a metal-organic framework (MOF)-derived p-CuO/n-Ce-FeO nanorod array photoanode for the photogenerated charge effectively separated and transported at the CuO/Ce-FeO p-n heterojunction interface through a built-in electric field. In addition, the MOF-derived porous CuO nanoparticles have a large surface area, and thus, can offer more surface active sites for water oxidation.

Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7.

Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methyl-lysine reader of Polycomb repressive complex 1. The PAM activity of UNC4976 resulted in enhanced efficacy across three orthogonal cellular assays by simultaneously antagonizing H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.

BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models.

Drug-tolerant "persister" tumor cells underlie emergence of drug-resistant clones and contribute to relapse and disease progression. Here we report that resistance to the BCL-2 targeting drug ABT-199 in models of mantle cell lymphoma and double-hit lymphoma evolves from outgrowth of persister clones displaying loss of 18q21 amplicons that harbor BCL2. Further, persister status is generated via adaptive super-enhancer remodeling that reprograms transcription and offers opportunities for overcoming ABT-199 resistance.

Ordered mesoporous silica cubic particles decorated with silver nanoparticles: a highly active and recyclable heterogeneous catalyst for the reduction of 4-nitrophenol.

In this work, using a modified Stöber process, we synthesized ordered mesoporous silica cubic particles (OMS-C) and prepared a nanocatalyst (Ag-OMS-C) based on OMS-C with a high surface area via an in situ auto-reduction strategy. The as-prepared Ag-OMS-C nanocomposites demonstrated open mesopores (3.51 nm), a large specific surface area (540 m2 g-1) and a high pore volume (0.

ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.

Androgen receptor splice variant 7 (AR-V7) is crucial for prostate cancer progression and therapeutic resistance. We show that, independent of ligand, AR-V7 binds both androgen-responsive elements (AREs) and non-canonical sites distinct from full-length AR (AR-FL) targets. Consequently, AR-V7 not only recapitulates AR-FL's partial functions but also regulates an additional gene expression program uniquely via binding to gene promoters rather than ARE enhancers.

Triple function nanocomposites of porous silica-CoFeO-MWCNTs as a carrier for pH-sensitive anti-cancer drug controlled delivery.

Cobalt ferrite nanoparticles loaded on multiwalled carbon nanotube (MWCNT) magnetic hybrids have been demonstrated to be promising magnetic resonance imaging contrast agents and drug carriers. However, the hydrophobic, less biocompatible characteristics and low loading capacity for the drug hamper their wide biological applications. To solve the above problem, an alternative strategy is to coat the MWCNTs@CoFeO nanoparticles with a mesoporous silica (mSiO) shell.

Cd(MoO)(TeO): A Polar 3D Compound Containing d-d SCALP-Effect Cations.

The new polar 3D cadmium molybdotellurite Cd(MoO)(TeO) was obtained by means of a high-temperature solid-state method. Cd(MoO)(TeO) is a monoclinic crystal system, and it exhibits the polar space group P2 (No. 4).

LPS-induced expression of CD14 in the TRIF pathway is epigenetically regulated by sulforaphane in porcine pulmonary alveolar macrophages.

Pulmonary alveolar macrophages (AMs) are important in defense against bacterial lung inflammation. Cluster of differentiation 14 (CD14) is involved in recognizing bacterial lipopolysaccharide (LPS) through MyD88-dependent and TRIF pathways of innate immunity. Sulforaphane (SFN) shows anti-inflammatory activity and suppresses DNA methylation.

Synthesis, Characterization and Cytotoxicity of Novel Multifunctional Fe₃O₄@SiO₂@GdVO₄:Dy Core-Shell Nanocomposite as a Drug Carrier.

In this study, multifunctional Fe₃O₄@SiO₂@GdVO₄:Dy nanocomposites were successfully synthesized via a two-step method. Their structure, luminescence and magnetic properties were characterized by X-ray diffraction (XRD), scanning electronic microscope (SEM), transmission electron microscopy (TEM), photoluminescence (PL) spectra and vibrating sample magnetometer (VSM). The results indicated that the as-prepared multifunctional composites displayed a well-defined core-shell structure.

Employing a new 12-connected topological open-framework copper borovanadate as an effective heterogeneous catalyst for oxidation of benzyl-alkanes.

A new 12-connected topological open-framework copper borovanadate with a unique B/V ratio (20/12) and a -B3O7(OH)-Na(μ-OH)[B(OH)2]-B3O7(OH)- connection mode has been hydrothermally obtained and characterized. It not only features the first 3-D copper(II) borovanadate which possesses the largest ratio of TM(2+) and borovanadate anion, but also displays highly catalytic activities for the oxidation of benzyl-alkanes.