A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer.

Evidence has suggested the potential of tumor-educated platelets as a biomarker trove for cancer diagnostics, but the difficulty in isolation limits its application. Since most of the circulating RNAs are derived from platelets, the change of RNA profile in platelets may lead to altered RNA expression in serum. Here, we identified a panel of platelet-associated long non-coding RNAs (lncRNAs) and evaluated its diagnostic capacity in serum of colorectal cancer (CRC) patients.

Effects of polygenic risk score, childhood trauma and resilience on depressive symptoms in Chinese adolescents in a three-year cohort study.

Background: Polygenic risk score (PRS) is a method of revealing multiple genes effect. The study of PRS and childhood trauma (CT) and resilience on adolescent depressive symptoms are fewer reported, especially the functional mechanism of resilience among them.

Methods: 718 Chinese adolescents aged 10-14 years were surveyed including CT, resilience, depressive symptoms, and phenotype data in three years of the cohort study.

[Relationships among personality traits, resilience and depressive symptoms of students in Wuhan City].

Objective: To investigate the relationships among personality traits, resilience and depressive symptoms of primary and high school students.

Methods: Totally 6019 students aged 10-17 from 5 primary schools(grades 5-6), 3 junior middle schools(grades 7-9) and 2 senior high schools(grade 1) years were selected by cluster sampling in Wuhan, from September 2015 to January 2016. Among them, there were 2420 primary school students, 2912 junior high school students and 687 senior high school students.

Interaction between FKBP5 polymorphisms and childhood trauma on depressive symptoms in Chinese adolescents: The moderating role of resilience.

Background: Previous gene-environment studies on depression have examined the interaction between FKBP5 gene and childhood trauma, but the results are inconsistent and few studies have focused on Asian adolescents. Psychological resilience may explain for the inconsistency. We examined the interaction between FKBP5 gene and childhood trauma on depressive symptoms in Chinese adolescents, and firstly explored the moderating role of resilience in the relationship.

Personality traits and depressive symptoms: The moderating and mediating effects of resilience in Chinese adolescents.

Background: Various studies showed that personality traits and resilience might have impacts on depressive symptoms, separately. However, the relationships among personality traits, resilience and depressive symptoms are still undefined. Thus, this study tried to explore the potential effect of resilience on the associations between personality traits and depressive symptoms in Chinese adolescents.

[Childhood trauma and its correlation with resilience among primary and middle school students in Wuhan city in 2015].

Objective: To investigate the prevalence of early trauma and resilience among adolescents in Wuhan, and explore the relationship between early trauma and resilience.

Methods: Totally 4871 students aged 10-16 years were chosen by cluster sampling in Wuhan city from September to October 2015. All subjects completed self-report questionnaires, including general information, the Childhood Trauma Questionnaire( CTQ), and the Connor Davidson Resilience Scale( CD-RISC).

Personality traits as possible mediators in the relationship between childhood trauma and depressive symptoms in Chinese adolescents.

Childhood trauma has been found to be a critical risk factor for depression in adolescents. Personality traits have been linked with mental health. However, the relationship between childhood trauma, personality traits, and depressive symptoms in adolescents is largely unclear.

Moderating and mediating effects of resilience between childhood trauma and depressive symptoms in Chinese children.

Background: Childhood trauma has been regarded as a risk factor for adolescent depression. Resilience has been found to be a protective factor for adolescent mental health. However, it is not clear about the role of resilience in the relationship between childhood trauma and depression.

Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus.

Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery.