Application of the Buccal Fat Pad in Oral Reconstruction: Covered With Collagen Membrane or Not?

Objective: To evaluate the clinical effectiveness of collagen membrane as biological dressing in protecting the covered buccal fat pad (BFP) from physical damage during postoperative healing phase in the reconstruction of oral soft tissue defect.

Methods: A retrospective cohort study was performed in patients undergoing oral defects reconstruction using BFP. The predictor variable was the application of collagen membrane or not.

S-allyl-cysteine attenuates carbon tetrachloride-induced liver fibrosis in rats by targeting STAT3/SMAD3 pathway.

S-allyl-cysteine (SAC) is one of the major compounds in aged garlic extract, and has been proved to be an endogenous donor of hydrogen sulfide (HS), which plays emerging roles in the gastrointestinal tract and liver. In this study, Sprague-Dawley rats were intraperitoneally injected with a mixture of carbon tetrachloride (CCl, 1 mL/kg body weight) and olive oil (1:1 v/v) every other day for 8 weeks to induce liver fibrosis. Treatment of SAC (50 mg/kg/day) could attenuate CCl-induced liver fibrosis, with improved semi-quantitative scores of fibrosis severity based on the staining of H&E, Oil Red O, and Sirius Red.