Publications by authors named "Huisheng Song"
Article Synopsis
- Understanding how cancer cells reprogram their metabolism has changed how we view tumor growth and potential treatments.
- The review highlights that cancer cells process glucose, amino acids, and lipids differently to meet their increased energy and biosynthetic demands, impacting their growth and the dynamics of the tumor microenvironment (TME).
- It proposes targeting these metabolic pathways as a new strategy for cancer therapy, aiming to enhance immune responses and provide fresh insights into treatment options.
Article Synopsis
- * A study showed that polydatin (PD) can mitigate damage from radon exposure by reducing oxidative stress and preventing changes associated with lung tissue injury, such as decreased migration and altered cell markers.
- * PD works by targeting the PI3K/AKT/mTOR signaling pathway, and is more effective when given before and after radon exposure, leading to better cell adhesion and less fibrotic changes in lung tissue.
Triple‑negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. In the present study, we revealed that the expression of miR‑30a was significantly decreased in TNBC, and TNBC patients with low expression of miR‑30a were associated with high histological grade and more lymph node metastasis. Moreover, we found that miR‑30a suppressed TNBC cell epithelial‑mesenchymal transition (EMT), as demonstrated by the overexpression of miR‑30a which increased the expression of epithelial marker E‑cadherin but decreased the expression of mesenchymal markers N‑cadherin and vimentin.
View Article and Find Full Text PDF[Efficacy of hypofractionated radiotherapy combined with docetaxel for treatment of bone metastasis of lung cancer].
Nan Fang Yi Ke Da Xue Xue Bao
July 2009
Objective: To evaluate the efficacy of hypofractionated radiotherapy combined with docetaxel for treatment of bone metastasis of lung cancer and explore the factors related to the prognosis.
Methods: Seventy-two patients with bone metastasis of lung cancer were divided into group A with hypofractionated radiotherapy at 3.0 Gy /fraction (once a day, 5 days per week for 30 Gy) and weekly docetaxel treatment at 60 mg for 2 weeks, and group B with radiotherapy alone at 2.
[Radiotherapy with concurrent chemotherapy for treatment of advanced nasopharyngeal carcinoma].
Di Yi Jun Yi Da Xue Xue Bao
June 2004
Objective: To evaluate the effect of radiotherapy combined with concurrent chemotherapy for the treatment of advanced nasopharyngeal carcinoma.
Methods: From February 2001 to August 2003, 80 cases of nasopharyngeal carcinoma (stage III and IVa) were randomized into two groups to receive radiotherapy with concurrent chemotherapy (Group A, n=40) consisted of leucovorin (CF, 100 mg/m(2), days 1-5), 5-fluorouracil (5-Fu, 500 mg/m(2), days 1-5), cisplatin (DDP, 60 mg/m(2), day 1) for one course followed by another 4 weeks later, or radiotherapy alone (Group B, n=40). In all cases, the radiotherapy followed the same protocol, with the nasopharyngeal (NP) total dose (DT) of 66-76 Gy given in 6.