A multifunctional graphene oxide-based nanodrug delivery system for tumor targeted diagnosis and treatment under chemotherapy-photothermal-photodynamic synergy.

Traditional cancer therapies, such as chemotherapy, often lack specificity, resulting in severe toxic side effects and limited therapeutic efficacy. There is an urgent need to develop innovative multifunctional nanomedicine carriers that integrate precise diagnosis, targeted therapy, real-time monitoring, and the synergistic effects of multiple therapeutic approaches. In this study, a composite nanodrug delivery system (GO-HA-Ce6-GNRs) based on graphene oxide (GO) was innovatively prepared, which was functionalized with the targeting molecule hyaluronic acid (HA), the photosensitizer chlorin e6 (Ce6), and the photothermal material gold nanorods (GNRs).

Folic acid-maltodextrin polymer coated magnetic graphene oxide as a NIR-responsive nano-drug delivery system for chemo-photothermal synergistic inhibition of tumor cells.

The combination of chemo-photothermal therapy with high efficiency and fewer side effects has a good application prospect in cancer treatment. It is of great significance to construct a nano-drug delivery system with cancer cell targeting, high drug loading and excellent photothermal conversion efficiency. Therefore, a novel nano-drug carrier MGO-MDP-FA was successfully constructed by coating folic acid-grafted maltodextrin polymers (MDP-FA) on the surface of FeO-modified graphene oxide (MGO).