Publications by authors named "Huiru Zhao"

The treatment of ammonia nitrogen wastewater (ANW) has garnered significant attention due to the ecology, and even biology is under increasing threat from over discharge ANW. Conventional ANW treatment methods often encounter challenges such as complex processes, high costs and secondary pollution. Considerable progress has been made in employing solar-induced evaporators for wastewater treatment.

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Background: The specific role of lysophosphatidic acid 2 (LPA) in deep vein thrombosis (DVT) remains unclear.

Methods: An inferior vena cava annulus retraction model of DVT was established in wild-type (WT) and global LPA knockout ( ) mice. We examined the incidence of DVT, wet weight of thrombus, length of thrombus, assessed endothelial permeability through Evans blue dye assay cell viability, and endothelial cell (EC) permeability of mouse inferior vena cava ECs Proteomics, histopathology, immunohistochemistry, and western blotting were employed to investigate the role of LPA in DVT.

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In this paper, we investigated the anticancer effect and the mechanism of our newly synthesized bibenzyl 8Ae against human lung cancer A549 cells. Compound 8Ae could induce apoptosis by inhibiting the glycolysis in A549 cells. Hexokinase 2 (HK2), the first key enzyme in glycolysis process, was significantly down-regulated by 8Ae.

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Article Synopsis
  • Bartter syndrome type 1 is an autosomal recessive disorder caused by mutations in the SLC12A1 gene, leading to symptoms like metabolic alkalosis and excessive urination in newborns.
  • A study identified pathogenic variants in a 12-day-old boy through whole-exome sequencing, finding both a known mutation and a novel splice site variant that disrupts SLC12A1 function.
  • The research demonstrates how the new splicing variant affects pre-mRNA processing, expanding the understanding of Bartter syndrome type 1 and aiding in genetic diagnostics and therapies.
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Background: D-dimer at a low level is important evidence for excluding the onset and progression of thrombosis. It is readily detectable and yields rapid results, although significant variability exists among different detection systems. Our study aims to enhance the consistency across various detection systems.

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This paper studies the dynamic response characteristics of the scanning angle in a liquid crystal cladding waveguide beam scanner. Based on liquid crystal dynamic theory, finite element analysis and vectorial refraction law, a dynamic response calculation model of scanning angle is constructed. The simulation results show that the dynamic responses of the scanning angle during the electric field-on and field-off processes are asymmetric, and exhibit "S"-shape and "L"-shape changing trends, respectively.

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Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy of all or part of chromosome 21. Competing endogenous RNAs (ceRNAs) play important roles in neuronal development and neurological defects. This study aimed to identify hub genes and synergistic crosstalk among ceRNAs in the DS fetal hippocampus as potential targets for the treatment of DS-related neurodegenerative diseases.

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Nanoparticles (NPs) hold great promise for agricultural applications, yet their potential impact on exogenous gene transfer within plant remains poorly understood. In this study, we utilized the non-conjugative plasmid pCAMBIA1300, harboring the bialaphos resistance (bar) gene expressed in plant and the kanamycin resistance (kanR) gene as selectable marker in bacteria. Our results revealed a significant increase in the transfer of plasmid (via carrier Escherichia coli DH5α), both intra- and inter-species within the endophyte, when Arabidopsis thaliana was exposed to environmentally relevant level of zinc oxide (ZnO) NPs at a concentration of 0.

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Spondyloepiphyseal dysplasia tarda (SEDT) is a condition involving late-onset, X-linked recessive skeletal dysplasia caused by mutations in the gene. In this paper, we identified a novel nonsense variant in a SEDT pedigree and analyzed the function of the variant in an attempt to explain the new pathogenesis of the TRAPPC2 protein in SEDT. Briefly, DNA and RNA samples from the peripheral blood of SEDT individuals were prepared.

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Multi-energy virtual power plant (MEVPP) has attracted more and more attention due to its advantages in renewable energy consumption and carbon emission reduction. However, the characteristics of multi-energy coupling and the access of renewable energy may lead to some challenges in the operation of MEVPP. In this paper, a data-driven distributionally robust chance constraints optimization model (DD-DRCCO) is proposed for the dispatching of MEVPP.

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Carbon trading price (CTP) prediction accuracy is critical for both market participants and policymakers. As things stand, most previous studies have only focused on one or a few carbon trading markets, implying that the models' universality is insufficient to be validated. By employing a case study of all carbon trading markets in China, this study proposes a hybrid point and interval CTP forecasting model.

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Venous thromboembolism is a common complication following trauma. We investigated the dynamics of plasma microparticles (MPs) levels and explored their potential as biomarkers of deep vein thromboembolism (DVT) after trauma. A total of 775 patients with traumatic fractures were recruited in this nested study.

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By analysing the mechanical and geometrical relations between the main cable, tower, and splay saddles, and considering the coupling effect of the tower and splay saddles, an improved algorithm is proposed to determine the cable saddles pre-offsets of suspension bridges. The equilibrium relationship of the cable saddles, the compatible deformation condition, and the basic equation of the main cable shape are considered to establish several coupled non-linear equations up to 19, and the tower and splay saddle pre-offsets are obtained by solving the above equations with the Newton-Raphson method. This paper presents the initial value selection principle and the constraint conditions for solving the cable saddle pre-offsets of the plane cable suspension bridge and the calculation process ensures convergence.

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Objective: Venous thromboembolism (VTE) is a common and severe complication of joint arthroplasty. Microparticles (MPs) containing phosphatidylserine (PS) and tissue factor (TF) can trigger coagulation in VTE. This study aims to measure and compare MP levels in joint arthroplasty patients with and without VTE.

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Japanese larch (), a non-native tree species, has been widely planted in the Qinling Mountains since the last century, but it does not meet the habitat needs of giant pandas (), mainly because of food, further causing habitat degradation and fragmentation. However, how soil microorganisms, considered as predictors of the soil environment, respond to Japanese larch remains poorly explored, especially compared with native forests. Here, we collected 40 soil samples from plantation, bamboo, and natural (excluding bamboo) forests in the Changqing Nature Reserve and Foping Nature Reserve in Qinling to compare soil bacterial community composition and diversity using high-throughput sequencing of bacterial 16S rRNA genes.

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As the proportion of renewable energy gradually increases, it brings challenges to the stable operation of the combined heat and power (CHP) system. As an important flexible resource, energy storage (ES) has attracted more and more attention. However, the profit of energy storage can't make up for the investment and operation cost, and there is a lack of measurement system for multiple values, which seriously hinders the development of energy storage industry.

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Silver nanoparticles (AgNPs) are effective antimicrobial substances that show promise in combatting multidrug resistance. The potential application and release of AgNPs into the environment may neutralize the selective advantage of antibiotic resistance. Systemic knowledge regarding the effect of NPs on the evolution of antibiotic resistance is lacking.

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Deep venous thrombosis (DVT) is a common complication in patients with traumatic injury. Tissue factor pathway inhibitor (TFPI) is a natural anticoagulant protein in the extrinsic coagulation pathway. However, the relationship between DVT after trauma and the anticoagulant activity of TFPI remains unclear.

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This work reports a selective and inert triptycene-based stationary phase (TPT) combining the triptycene framework with tocopheryl polyethylene glycol succinate (TPGS) units for capillary gas chromatography (GC). The TPT stationary phase was physically coated onto a capillary column by static coating method with the column efficiency of 4200 plates/m and moderate polarity. As demonstrated, the TPT column exhibited high inertness towards organic bases, including basic heterocycles, aliphatic and aromatic amines, showing distinct advantages over the TPGS and commercial columns.

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This work presents the investigation of using tocopheryl polyethylene glycol succinate as the stationary phase for gas chromatography separations of isomers with different varieties and gas chromatography-mass spectrometry analysis of a wide range of components in lavender essential oil. Its capillary column exhibited moderate polarity and column efficiency of 4000 plates/m determined by n-dodecane at 120°C. As demonstrated, it showed outstanding separation performance toward challenging isomers such as xylenes, alkanes, phenols, and anilines and a wide range of components in essential oils with distinct advantages over the commercial polyethylene glycol and polysiloxane columns.

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Rhizoma Drynariae, the dried rhizome of Drynaria fortunei (Kunze), is rich in flavonoids and has varieties of pharmacological activities. To optimize the extract conditions for bioactive flavonoids, a response surface methodology (RSM) was utilized to assess the effects of three independent variables (liquid-to-solid ratio (mL/g), extract temperature (°C) and ethanol concentration (%) on the total flavonoids content (TFC). To test the chelation with metal ion, the UV-visible spectrophotometer was used to detect metal ion chelation of extracted flavonoids.

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Unbalanced and inadequate development in China has resulted in significant temporal and spatial differences in carbon intensity, impeding the achievement of carbon reduction targets. This paper explores the spatial distribution and convergence of China's provincial carbon intensity during 2000-2017 and its influencing factors employing spatial panel techniques. The spatial distribution analysis supports the existence of significant spatial agglomeration and radiation effects in China's provincial carbon intensity, and several provinces play key roles in the spatial distribution of carbon intensity, which are an important focus of carbon emission reduction policies.

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Effective and safe hemodialysis is essential for patients with acute kidney injury and chronic renal failures. However, the development of effective anticoagulant agents with safe antidotes for use during hemodialysis has proven challenging. Here, we describe DNA origami-based assemblies that enable the inhibition of thrombin activity and thrombus formation.

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Background: Deep vein thrombosis (DVT) is a common complication in patients with traumatic injury. The purpose of this study was to develop a potential predictor of DVT.

Methods: This case-control study enrolled adult trauma patients and healthy volunteers.

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