Publications by authors named "Huirong Xi"
[Preparation and characterization of icariin nanosuspension and lyophilized powder].
Zhongguo Zhong Yao Za Zhi
October 2020
Article Synopsis
- The study investigated the optimal process conditions for preparing icariin nanosuspensions and lyophilized powder using the anti-solvent precipitation-high shear method to improve their stability and dissolution rates.
- The characteristics of the nanosuspension were assessed based on particle size, polydispersity index, and sedimentation ratio, with findings indicating a stable and uniform nanosuspension with an average particle size of 62.51 nm and a drug loading of 16%.
- Experiments demonstrated that the nano-lyophilized powder significantly enhanced the solubility of icariin, achieving a 100% cumulative release rate within 10 minutes, showcasing the effectiveness of the preparation method in improving water solubility.
Microgravity is one of the main threats to the health of astronauts. Pulsed electromagnetic fields (PEMFs) have been considered as one of the potential countermeasures for bone loss induced by space flight. However, the optimal therapeutic parameters of PEMFs have not been obtained and the action mechanism is still largely unknown.
View Article and Find Full Text PDF[Effect of Compound Medicine of Tanshinone 2A and Resveratrol on Peak Bone Mass in Growing Rats].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
August 2018
Article Synopsis
- The study aimed to investigate how a combination of tanshinone 2A and resveratrol affects bone mass in growing rats, focusing on potential anti-osteoporosis mechanisms from traditional Chinese medicine.
- 40 one-month-old female Wistar rats were divided into four groups receiving different treatments, with body weight and bone mineral density measured regularly over two months.
- Results showed significant improvements in bone density and quality for the compound group compared to the control, indicated by increased levels of osteocalcin and tartrate-resistant acid phosphatase 5b.
[Effect of Xianling Gubao capsule on bone metabolism in ovariectomized rats].
Zhongguo Zhong Yao Za Zhi
July 2018
Article Synopsis
- The study assessed the impact of Xianling Gubao capsule on preventing postmenopausal osteoporosis using 48 ovariectomized female Wistar rats divided into four groups for comparison.
- The results showed that both Xianling Gubao capsule and ethinylestradiol groups improved bone mineral density (BMD) and biomechanical properties compared to the OVX control group, indicating their potential effectiveness in enhancing bone health.
- Despite no significant changes in body weight or vital organ indices, the treatments improved trabecular bone numbers, though the difference between the two treatment groups (XLGB and EE) was not statistically significant.
Article Synopsis
- The study aimed to compare the effects of resveratrol, puerarin, and a combination of both on peak bone mass in rats.
- After dividing rats into four groups (control, puerarin, resveratrol, and a compound group), the researchers monitored body weight and measured bone density over three months, concluding that both resveratrol and puerarin significantly enhanced bone mineral density compared to the control group.
- The combined treatment of resveratrol and puerarin showed the most considerable improvements in bone structure and strength, highlighting the potential of these compounds for enhancing bone health.
The application of pulsed electromagnetic fields (PEMFs) in the prevention and treatment of osteoporosis has long been an area of interest. However, the clinical application of PEMFs remains limited because of the poor understanding of the PEMF action mechanism. Here, we report that PEMFs promote bone formation by activating soluble adenylyl cyclase (sAC), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and cAMP response element-binding protein (CREB) signaling pathways.
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- Epimedium sagittatum brevicornum is a traditional Chinese herb known for its role in healing fractures and treating osteoporosis.
- This study aimed to explore whether the total flavonoid extract (TFE) from Epimedium could increase peak bone mass in young rats, which is crucial for preventing osteoporosis later in life.
- Results showed that TFE at middle and high doses significantly enhanced bone mineral density and improved bone properties, promoting bone formation through a specific biochemical pathway without affecting bone resorption.
[Effect of resveratrol on peak bone mass in growing rats].
Zhejiang Da Xue Xue Bao Yi Xue Ban
May 2017
To investigate the effect of resveratrol on peak bone mineral density and bone mass in growing rats. Thirty-six female healthy Wistar rats were randomly divided into control group, icariin group and resveratrol group with 12 rats in each group. Icariin (25 mg·kg·d), resveratrol (8.
View Article and Find Full Text PDFObjective: To study effects of 50 Hz 1.8 mT sinusoidal electromagnetic fields (SEMFs) on bone mineral density (BMD) in SD rats.
Methods: Thirty SD rats weighted(110±10) and aged 1 month were randomly divided into control group and electromagnetic field group, 15 in each group.
[Effects of icariin total flavonoids capsule on bone mineral density and bone histomorphometry in growing rats].
Zhejiang Da Xue Xue Bao Yi Xue Ban
May 2016
To investigate the effect of icariin total flavonoids capsules (ITFC) on bone mineral density (BMD) and bone histomorphometry in growing rats and its anti-osteoporosis mechanism. Thirty female SD rats were randomly divided into 3 groups:normal control group, ITFC-1 group and ITFC-2 group. Rats in ITFC-1 group and ITFC-2 group were fed with 50 mg·kg·d or 100 mg·kg·d ITFC, respectively, and those in normal control group were fed with equal volume of distilled water.
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