Publications by authors named "Huiren Lei"
Article Synopsis
- Researchers investigated the potential of serum 14-3-3β protein as a diagnostic biomarker for stable Chronic Obstructive Pulmonary Disease (COPD), particularly in patients unable to undergo standard lung function tests.
- Their study found significantly higher levels of 14-3-3β in stable COPD patients compared to healthy controls, with variations based on disease severity (GOLD stages).
- The results indicate that serum 14-3-3β levels correlate with systemic inflammation and lung function, suggesting its utility in diagnosing COPD with a notable sensitivity (84.9%) and specificity (68.3%).*
The Role of Macrophage Migration Inhibitory Factor (MIF) in Asthmatic Airway Remodeling.
Allergy Asthma Immunol Res
January 2021
Purpose: Recent studies have demonstrated that macrophage migration inhibitory factor (MIF) is of importance in asthmatic inflammation. The role of MIF in modulating airway remodeling has not yet been thoroughly elucidated to date. In the present study, we hypothesized that MIF promoted airway remodeling by intensifying airway smooth muscle cell (ASMC) autophagy and explored the specific mechanisms.
View Article and Find Full Text PDFIdiopathic pulmonary fibrosis (IPF) is the most common type of idiopathic interstitial pneumonia and has one of the poorest prognosis. However, the molecular mechanisms underlying IPF progression remain largely unknown. In this study, we determined that IL-24, an IL-20 subfamily cytokine member, was increased both in the serum of IPF patients and the bronchoalveolar lavage fluid (BALF) of mice following bleomycin (BLM)-induced pulmonary fibrosis.
View Article and Find Full Text PDFDiagnostic accuracy of 14-3-3 η protein in rheumatoid arthritis: A meta-analysis.
Int J Rheum Dis
November 2020
Aim: To evaluate the overall diagnostic performance of 14-3-3 η protein in patients with rheumatoid arthritis (RA).
Methods: PubMed, EMBASE, and Web of Science were searched to acquire eligible studies. Articles published in English before 20 February 2020 were included.