Vitamin K (K1 and K2) and Vitamin D are essential for bone health, particularly in relation to osteoporosis, and measuring their levels in the blood can help understand their roles in skeletal muscle metabolism.
A new, efficient high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to precisely measure serum levels of VK1, MK-4, MK-7, 25(OH)D2, and 25(OH)D3 in a cohort of 200 patients.
Results showed that VK2 (MK-7) levels decreased earlier than vitamin D in postmenopausal women with osteoporosis, suggesting that MK-7 could be a useful biomarker