Publications by authors named "Huiqing Yuan"

The development of robust and inexpensive photocatalysts for H production under visible light irradiation remains a significant challenge. This study presents a series of square planar copper anthraquinone complexes (RN)CuL (R = ethyl, L = alizarin dianion (CuAA); R = -butyl, L = purpurin dianion (CuPP), (2-hydroxyanthraquinone)formamide dianion (CuAHA)) as molecular photocatalysts to achieve high long-term stability in visible-light-driven H production. These complexes are self-sensitized by the anthraquinone ligands and serve as proton reduction photocatalysts without additional photosensitizers or catalysts.

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Article Synopsis
  • Immune checkpoint inhibitors that target PD-1 and PD-L1 show great potential in cancer treatment, but many patients exhibit limited responses due to insufficient understanding of how PD-L1 is regulated.
  • The study reveals that VPS11 and VPS18 proteins play a crucial role in regulating PD-L1 by affecting its stability and recycling in cells, which impacts the effectiveness of immune therapies.
  • The research suggests that using a drug called RDN, which inhibits VPS18, may improve cancer treatment outcomes when combined with existing therapies, especially in aggressive tumors, offering a new strategy to boost immune response against cancer.
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Localized surface plasmon resonances in plasmonic nanoparticles enable effective photon harvesting and generate energetic electrons and holes. However, fast charge recombination and surface contamination due to reactant-involved synthesis can significantly hinder the activity. Herein, we report a facile, solution-processed synthesis of hybrid uncoated silver nanoparticles combined with silicon nanocrystals to address these issues.

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This study aimed to predict therapeutic efficacy among diffuse large B-cell lymphoma (DLBCL) after R-CHOP (-like) therapy using baseline F-fluorodeoxyglucose positron emission tomography (F-FDG PET) radiomics. A total of 239 patients with DLBCL were enrolled in this study, with 82 patients having refractory/relapsed disease. The radiomics signatures were developed using a stacking ensemble approach.

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Article Synopsis
  • The study aimed to investigate how well baseline F-FDG PET/CT radiomics can predict the prognosis of diffuse large B-cell lymphoma (DLBCL) in patients with extranodal involvement (ENI).
  • A cohort of 126 DLBCL patients was analyzed, using LASSO Cox regression to identify significant features, leading to a combined model that predicts progression-free survival (PFS) and overall survival (OS).
  • Results showed that the combined model outperformed the radiomics alone and traditional clinical variables in predicting PFS and OS, indicating its effectiveness in assessing risk and likely outcomes in these patients.
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[Ga]Ga-DOTA-FGFR1-peptide is a novel positron emission tomography (PET) radiotracer targeting fibroblast growth factor receptor 1 (FGFR1). This study evaluated the safety, biodistribution, radiation dosimetry, and imaging potential of [Ga]Ga-DOTA-FGFR1-peptide. The FGFR1-targeting peptide DOTA-(PEG2)-KAEWKSLGEEAWHSK was synthesized by manual solid-phase peptide synthesis with high-performance liquid chromatography purification, and labeled with Ga with DOTA as chelating agent.

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The utilization of low-energy photons in light-driven reactions is an effective strategy for improving the efficiency of solar energy conversion. In nature, photosynthetic organisms use chlorophylls to harvest the red portion of sunlight, which ultimately drives the reduction of CO. However, a molecular system that mimics such function is extremely rare in non-noble-metal catalysis.

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Purpose: This study assesses the diagnostic performance of Ga-FAPI-04 PET/CT compared to F-FDG PET/CT in primary, recurrent, and metastatic ovarian cancer.

Methods: Seventy-nine ovarian cancer patients who performed Ga-FAPI-04 and F-FDG PET/CT were recruited. The target-to-background ratio (TBR), maximum standardized uptake value (SUV), the number of positive lesions, visual assessment, the peritoneal cancer index (PCI) score, staging/restaging, and treatment strategies were compared from the corresponding PET/CT.

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The utilization of low-energy sunlight to produce renewable fuels is a subject of great interest. Here we report the first example of metal chalcogenide quantum dots (QDs) capped with a pyridinethiolate carboxylic acid (pyS-COOH) for red-light-driven H production in water. The precious-metal-free system is robust over 240 h, and achieves a turnover number (TON) of 43910±305 (vs Ni) with a rate of 31570±1690 μmol g h for hydrogen production.

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Herein we studied visible-light-driven CO reduction using a series of tetra-phenylporphyrin iron catalysts and inexpensive anthraquinone dyes. Varying the functional groups on the phenyl moieties of the catalysts significantly enhances the photocatalytic activity, achieving an optimal turnover number (TON) of 10 476 and a selectivity of 100% in the noble-metal-free systems. The highest activity found in a bromo-substituted catalyst is attributed to favorable electron transfer from the photosensitizer to the iron porphyrin.

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Inducing paraptosis, a nonapoptotic form of cell death, has great therapeutic potential in cancer therapy, especially for drug-resistant tumors. However, the specific molecular target(s) that trigger paraptosis have not yet been deciphered yet. Herein, by using activity-based protein profiling, we identified the GDP-dissociation inhibitor beta (GDI2) as a manipulable target for inducing paraptosis and uncovered benzo[]quinolizidine BQZ-485 as a potent inhibitor of GDI2 through the interaction with Tyr245.

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Ferroptosis suppressor protein 1 (FSP1, also known as AIMF2, AMID or PRG3) is a recently identified glutathione-independent ferroptosis suppressor, but its underlying structural mechanism remains unknown. Here we report the crystal structures of Gallus gallus FSP1 in its substrate-free and ubiquinone-bound forms. The structures reveal a FAD-binding domain and a NAD(P)H-binding domain, both of which are shared with AIF and NADH oxidoreductases, and a characteristic carboxy-terminal domain as well.

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Groundwater chemical composition can be changed due to long-term coal mining activities, but it was unclear how it was induced in Taiyuan Formation limestone (TFL) regarding the lack of relevant quantitative studies. The aim of this research is to improve understanding of the chemical composition changes in groundwater of L limestone in the coal mining area based on the available hydrochemical and hydrodynamical reports and studies during the period 1978-2020. The systematical analysis of the groundwater composition and field allows to make the hydrogeological characterization with the relatively independent blocks by the factor groups "Planar division & Vertical zonation" and "High water pressure, Poor recharge & Little water inflow," which determines different hydrochemical types and high TDS concentration.

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Objectives: Steroid-resistant nephrotic syndrome (SRNS) is a clinical syndrome characterized by the lack of response to standard steroid therapy, usually progressing to end-stage renal disease. We reported two cases of female identical twins with SRNS caused by variants in one family, reviewed the relevant literature, and summarized their clinical phenotypes, pathological types, and genotypic characteristics.

Methods: Two cases of nephrotic syndrome caused by variants were admitted to Tongji Hospital, affiliated with Tongji Medical College of Huazhong University of Science and Technology.

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The direct utilization of solar energy to convert CO into renewable chemicals remains a challenge. One essential difficulty is the development of efficient and inexpensive light-absorbers. Here we show a series of aminoanthraquinone organic dyes to promote the efficiency for visible light-driven CO reduction to CO when coupled with an Fe porphyrin catalyst.

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We report the unprecedented electrocatalytic activity of a series of molecular nickel thiolate complexes (1-5) in reducing CO to C hydrocarbons on carbon paper in pH-neutral aqueous solutions. Ni(mpo) (3, mpo=2-mercaptopyridyl-N-oxide), Ni(pyS) (4, pyS=2-mercaptopyridine), and Ni(mp) (5, mp=2-mercaptophenolate) were found to generate C products from CO for the first time in molecular complex. Compound 5 exhibits Faradaic efficiencies (FEs) of 10.

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Background: Obstetrical infection is one of the causes of maternal death and a difficult problem for many clinicians. Changes in the demographic and obstetric background of pregnant women following the Universal Two-Child Policy may have an impact on some fertility phenomena. And with the increase in the number of deliveries, the limited medical resources become more scarce.

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The direct utilization of the full solar spectrum to obtain renewable fuels remains a challenge because the conversion of the low-energy light (red and near-infrared) is difficult. Current light-driven systems show activity for hydrogen generation with the high-energy part of sunlight. Here we report the use of a simple anthraquinone organic dye in an artificial photosynthetic system that promotes efficient red-light-driven production of hydrogen.

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Organic dyes have been investigated extensively as promising photosensitizers in noble-metal-free photocatalytic systems for hydrogen production. However, other than functional group optimization, there are very few methods reported to be effective in improving their photocatalytic activity. Herein, we report the incorporation of Cu into purpurin and gallein dyes for visible-light-driven hydrogen production.

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Electrochemical CO reduction is a promising approach to obtain sustainable chemicals in energy conversion. Improving the selectivity of CO reduction toward a particular C product such as ethylene remains a significant challenge. Herein, we report a series of imidazolium hexafluorophosphate compounds as surface modifiers for planar Cu foils to boost the Faradaic efficiency (FE) of ethylene from 5 to 73%, which is among the highest reported using polycrystalline Cu.

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Combination therapy is frequently used in cancer treatments. Delivery of combined anticancer agents loaded in a nanocarrier would be a promising option for combination therapy. Here, we designed PEGylated nano-liposomes for co-delivery Docetaxel (Doc) and Resveratrol (Res) to evaluate antitumor efficiency of the combined drugs in prostate cancer.

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Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is relatively rare in children. This article aimed to analyze clinical and renal histology findings and different responses to induction treatment associated with the long-term renal outcomes in children with AAV in a single center.

Methods: All pediatric patients with AAV admitted to Tongji Hospital from January 2002 to January 2021 were included in the study.

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Anterior gradient 2 (AGR2), a protein disulfide isomerase (PDI), is a multifunctional protein under physiological and pathological conditions. In this study we investigated the roles of AGR2 in regulating cholesterol biogenesis, lipid-lowering efficiency of lovastatin as well as in protection against hypercholesterolemia/statin-induced liver injury. We showed that AGR2 knockout significantly decreased hepatic and serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in mice with whole-body or hepatocyte-specific Agr2-null mutant, compared with the levels in their wild-type littermates fed a normal chow diet (NCD) or high-fat diet (HFD).

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