Publications by authors named "Huiqin Kang"
Article Synopsis
- The paper discusses a professor's clinical approach to treating wrist rheumatoid arthritis using acupotomy mobilization, focusing on muscle regions associated with three specific hand meridians.
- The professor argues that this form of arthritis is linked to issues in the meridian muscle areas, emphasizing the need for targeted treatment of these regions.
- By applying acupotomy mobilization and stimulating both the foci (knotted sites) and acupoints, the therapy aims to address both the musculoskeletal and meridian dysfunctions simultaneously.
USP7 as an emerging therapeutic target: A key regulator of protein homeostasis.
Int J Biol Macromol
April 2024
Article Synopsis
- Maintaining protein balance is key for cell function, and disruptions in the ubiquitin-proteasome pathway can lead to diseases.
- Deubiquitinating enzymes, especially ubiquitin-specific protease 7 (USP7), are critical for regulating protein levels by modifying proteins involved in important cellular processes like apoptosis and DNA repair.
- USP7 is connected to various diseases, including cancer and neurodegenerative conditions, making it essential to understand its functions for developing new therapeutic strategies and inhibitors.
Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two catalytic domains and a zinc-finger ubiquitin binding domain (ZnF-UBP) domain. The deacetylation function of HDAC6 has been extensively studied with common substrates such as α-tubulin, cortactin, and Hsp90. Apart from its deacetylase activity, HDAC6 ZnF-UBP binds to unanchored ubiquitin of specific sequences and serves as a carrier for transporting aggregated proteins.
View Article and Find Full Text PDFHistone deacetylase 6 (HDAC6) is the only member of the HDAC family that resides primarily in the cytoplasm with two catalytic domains and a ubiquitin-binding domain. HDAC6 is highly expressed in various solid tumors and participates in a wide range of biological activities, including hormone receptors, the p53 signaling pathway, and the kinase cascade signaling pathway due to its unique structural foundation and abundant substrate types. Additionally, HDAC6 can function as an oncogenic factor in solid tumors, boosting tumor cell proliferation, invasion and metastasis, drug resistance, stemness, and lowering tumor cell immunogenicity, so assisting in carcinogenesis.
View Article and Find Full Text PDF6-Methyladenosine (mA) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, mA modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two mA demethylases have been reported, fat mass and obesity-associated protein (FTO) and alkylation protein AlkB homolog 5 (ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability.
View Article and Find Full Text PDFHistone deacetylase 6 (HDAC6) has emerged as a critical regulator of many cellular pathways in tumors due to its unique structure basis and abundant substrate types. Over the past few decades, the role played by HDAC6 inhibitors as anticancer agents has sparked great interest of biochemists worldwide. However, they were less reported for gastric cancer therapy.
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