Feasibility evaluation of kilovoltage cone-beam computed tomography dose calculation following scatter correction: investigations of phantom and representative tumor sites.

Background: To study the feasibility of kilovoltage cone-beam computed tomography (KV-CBCT) dose calculation following scatter correction.

Methods: CIRS 062 and Catphan 504 phantoms were used in this study, and 40 randomly selected subjects representing a variety of cases (ten head cancer cases, ten chest cancer cases, ten abdominal cancer cases and ten pelvic cavity cancer cases) were enrolled. We developed in-house software called the cone-beam CT imaging toolkit (CITK) to improve the quality of CBCT images.

Synergy between Clinical Microenvironment Targeted Nanoplatform and Near-Infrared Light Irradiation for Managing Infections.

Chronic infections caused by pose severe threats to human health. Traditional antibiotic therapy has lost its total supremacy in this battle. Here, nanoplatforms activated by the clinical microenvironment are developed to treat infection on the basis of dynamic borate ester bonds.

Bioinformatics analysis of Myelin Transcription Factor 1.

Background And Objective: We aimed to further study the role of Myelin Transcription Factor 1(MyT1) in tumor and other diseases and epigenetic regulation, and better understand the regulatory mechanism of MyT1.

Methods: Using bioinformatics analysis, the structure and function of MyT1sequence were predicted and analyzed using bioinformatics analysis, and providing a theoretical basis for further experimental verification and understanding the regulatory mechanism of MyT1. The first, second and third-level structures of MyT1 were predicted and analyzed by bioinformatics analysis tools.

Geometric accuracy evaluation of a six-degree-of-freedom (6-DoF) couch with cone beam computed tomography (CBCT) using a phantom and correlation study of the position errors in pelvic tumor radiotherapy.

Background: To assess the position accuracy of the six-degree-of-freedom (6-DoF) couch based on cone beam computed tomography (CBCT) and exploit the correlation of the six degrees errors.

Methods: CT scans of an anthropomorphic phantom and patients were obtained at 3 mm slice thicknesses using a Philips scanner at the head, first supine and prostrate positions. An Eclipse Treatment Planning System was used to create a treatment plan.

A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation.

Frequent subcutaneous insulin injection and islet transplantation are promising therapeutic options for type 1 diabetes mellitus. However, poor patient compliance, insufficient appropriate islet β cell donors and body immune rejection limit their clinical applications. The design of a platform capable of encapsulating insulin-secreting cells and achieving real-time blood glucose regulation, is a so far unmet need.

A Bioadhesive Nanoplatform Enhances the Permeation of Drugs Used to Treat Diabetic Macular Edema.

The management of diabetic macular edema (DME), a condition that leads to an irreversible and severe visual impairment, remains a substantial challenge worldwide. In this study, we developed a bioadhesive nanoplatform with enhanced drug penetration to explore alternative treatment modalities for DME. This nanoparticulate formulation consisted of a sequence of an amphiphilic phenylboronic acid-based block and random glycopolymer with a high loading capacity for dexamethasone (DEX) of up to 20% and sustained drug release at a clinically relevant dose.

Characterization of microvessels and parenchyma in in-line phase contrast imaging CT: healthy liver, cirrhosis and hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is a cancer with a poor prognosis, and approximately 80% of HCC cases develop from cirrhosis. Imaging techniques in the clinic seem to be insufficient for revealing the microstructures of liver disease. In recent years, phase contrast imaging CT (PCI-CT) has opened new avenues for biomedical applications owing to its unprecedented spatial and contrast resolution.

Plan quality and robustness in field junction region for craniospinal irradiation with VMAT.

Purpose: To propose a "staggered overlap" technique in volumetric modulated arc therapy (VMAT) for craniospinal irradiation (CSI) and compare the dose distribution and plan robustness with "overlap" technique and "gradient optimization" approach.

Methods And Materials: 6 patients previously treated in our clinic were retrospectively selected. 9 VMAT plans of each patient were optimized with "staggered overlap", "overlap" and "gradient optimization" in overlapping region of 3 cm, 6 cm, and 9 cm separately.

Umbilical cord mesenchymal stem cell (UC-MSC) transplantations for cerebral palsy.

This study reports a case of a 4-year-old boy patient with abnormalities of muscle tone, movement and motor skills, as well as unstable gait leading to frequent falls. The results of the electroencephalogram (EEG) indicate moderately abnormal EEG, accompanied by irregular seizures. Based on these clinical characteristics, the patient was diagnosed with cerebral palsy (CP) in our hospital.

The Distribution of Transplanted Umbilical Cord Mesenchymal Stem Cells in Large Blood Vessel of Experimental Design With Traumatic Brain Injury.

The authors aim to track the distribution of human umbilical cord mesenchymal stem cells (MSCs) in large blood vessel of traumatic brain injury -rats through immunohistochemical method and small animal imaging system. After green fluorescent protein (GFP) gene was transfected into 293T cell, virus was packaged and MSCs were transfected. Mesenchymal stem cells containing GFP were transplanted into brain ventricle of rats when the infection rate reaches 95%.