A bimodal time-gated luminescence-magnetic resonance imaging nanoprobe based on a europium(III) complex anchored on BSA-coated MnO nanosheets for highly selective detection of HO.

A novel nanocomposite, [Eu(BTD)(DPBT)]-BSA@MnO, is reported to serve as an effective nanoprobe for bimodal time-gated luminescence (TGL) and magnetic resonance (MR) imaging of HO and . The nanoprobe was fabricated by immobilizing visible-light-excitable Eu complexes in bovine serum albumin (BSA)-coated lamellar MnO nanosheets. The TGL of the Eu complex was effectively quenched by the MnO nanosheets.

An activatable nanoprobe based on nanocomposites of visible-light-excitable europium(III) complex-anchored MnO nanosheets for bimodal time-gated luminescence and magnetic resonance imaging of tumor cells.

Bimodal imaging probes that combine magnetic resonance imaging (MRI) and photoluminescence imaging are quite appealing since they can supply both anatomical and molecular information to effectively ameliorate the accuracy of detection. In this study, an activatable nanoprobe, [Eu(BTD)(DPBT)]@MnO, for bimodal time-gated luminescence imaging (TGLI) and MRI has been constructed by anchoring visible-light-excitable Eu complexes on lamellar MnO nanosheets. Due to the luminescence quenching effect and non-magnetic resonance (MR) activity of MnO nanosheets, the developed nanoprobe presents quite weak TGL and MR signals.

A tumor-targetable probe based on europium(III)/gadolinium(III) complex-conjugated transferrin for dual-modal time-gated luminescence and magnetic resonance imaging of cancerous cells and .

The synergy of magnetic resonance imaging (MRI) and time-gated luminescence imaging (TGLI) provides a robust platform with extensive spatial resolution (from submicrometer to hundred-micron) and unlimited penetration depth for visual detection of lesion tissues and target biomolecules. In this work, highly stable lanthanide (Eu and Gd) complexes with a terpyridine polyacid ligand, CNSTTA-Ln, were chosen as signal reporters for TGLI (Ln = Eu) and MRI (Ln = Gd), respectively. After conjugating CNSTTA-Ln with a tumor-targetable glycoprotein, transferrin (Tf), the obtained bioconjugate, showed low cytotoxicity and high stability and exhibited strong long-lived luminescence (Tf-CNSTTA-Eu, = 10.